127682-80-8

Upstream product

• 3396-72-3 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate 
• 127682-76-2 (3R,5S)-5-Dimethoxymethyl-tetrahydro-furan-3-ol 
• 127682-77-3 (3S-trans)-tetrahydro-5-(dimethoxymethyl)-3-furanol 4-methylbenzenesulfonate 
• 127682-78-4 (2R-trans)-tetrahydro-4-<<(4-methylphenyl)sulfonyl>oxy>-2-furanmethanol 
• 127682-77-3 2(R)-<(dimethoxy)methyl>-4(S)-tetrahydrofuran 
• 127682-78-4 (2R-trans)-tetrahydro-4-[[(4-methylphenyl)-sulfonyl]oxy]-2-furanmethanol 
• 127682-76-2 (2R,4S)-4-hydroxy-2-dimethoxymethyltetrahydrofuran 

Downstream Products

• 149519-47-1 {(2R,4R)-4-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-tetrahydro-furan-2-yl}-methanol 
• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)-tetrahydro-2-furanmethanol 
• 127682-75-1 IsoddA 
• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)tetrahydrofuran-2-methanol 

Relevant academic research and scientific papers

Synthesis and anti-HIV activity of isonucleosides

A series of isomeric 2',3'-dideoxynucleosides which contains a modified carbohydrate moiety has been prepared. This class of compounds was designed to mimic the activity of known anti-HIV dideoxynucleosides, while imparting enhanced chemical and enzymatic

Isomeric dideoxynuclesides

Isomeric derivatives of 2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine wherein the adenine or guanine base is attached to the 1' position of the iso-dideoxysugar residue by the 9-N position, the novel intermediates used in the synthesis of these compounds, and a method for treating a subject infected with a retrovirus by administering the compounds of the invention.

SYNTHESYS OF ISO-DDA, MEMBER OF A NOVEL CLASS OF ANTI-HIV AGENTS

Iso-ddA (3) represents a new class of potential anti-AIDS drugs.Synthetic approaches to this compound involving nucleophilic additions to a novel carbohydrate framework are discussed.