127708-83-2

Upstream product

• 115351-17-2 Trifluoro-methanesulfonic acid (S)-2-benzyloxy-1-((3aR,5S,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester 
• 18006-23-0 3,6-Di-O-benzyl-1,2-O-isopropylidene-β-L-ido-furanose 
• 16958-26-2 1,2-O-isopropylidene-3,6-di-O-benzyl-5-azido-5-deoxy-α-D-glucofuranose 

Downstream Products

• 127214-70-4 methyl 5-azido-3,6-di-O-benzyl-5-deoxy-D-glucofuranoside 
• 128984-74-7 5-Amino-5-deoxy-3,6-di-O-benzyl-D-glucono-δ-lactam 
• 14904-83-7 nojirimycin-δ-lactam 
• 127656-54-6 (E/Z)-2,3,4,6-tetra-O-benzyl-5-deoxy-5-trifluoroacetamido-D-glucose oxime 
• 127656-46-6 (E/Z)-5-Azido-2,3,4,6-tetra-O-benzyl-5-deoxy-D-glucose oxime 
• 127656-55-7 2,3,4,6-Tetra-O-benzyl-5-deoxy-5-trifluoroacetamido-D-glucononitrile 
• 127656-53-5 2,3,4,6-Tetra-O-benzyl-5-deoxy-5-trifluoroacetamido-D-glucose 
• 127656-52-4 2,3,4,6-Tetra-O-benzyl-5-deoxy-5-trifluoroacetamido-D-glucitol 
• 127656-45-5 5-Azido-2,3,4,6-tetra-O-benzyl-5-deoxy-D-glucose 
• 127656-51-3 5-Azido-2,3,4,6-tetra-O-benzyl-5-deoxy-D-glucitol 
• 162398-60-9 N-(7-Oxadecyl)-2,4-di-O-butyryl-3,6-di-O-benzyl-1-deoxynojirimycin 
• 162398-59-6 N-(7-Oxadecyl)-2,4-di-O-acetyl-3,6-di-O-benzyl-1-deoxynojirimycin 
• 162398-64-3 N-(7-Oxadecyl)-2-O-butyryl-3,6-di-O-benzyl-1-deoxynojirimycin 

Relevant academic research and scientific papers

α-glucosidase inhibitors

This invention relates to novel polyglycosidyl derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.

N-derivatives of 1-deoxy nojirimycin

This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome

Synthesis of (1-13C)-1-deoxynojirimycin

(1-13C)-1-Deoxynojirimycin was synthesised from easily available 5- azido-5-deoxy-1,2-O-isopropylidene-α-D-glucofuranose via a one-carbon chain shortening/chain extension sequence employing 13C-enriched potassium cyanide.

N-derivatives of 1-deoxy nojirimycin

This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome

SYNTHESIS OF DEOXYNOJIRIMYCIN AND OF NOJIRIMYCIN δ-LACTAM

The syntheses of nojirimycin δ-lactam and of deoxynojirimycin from a divergent ido-furanose intermediate are reported.

The synthesis of protected 5-azido-5-deoxy-D-glucononitriles as precursors of glycosidase inhibitors

The successful syntheses of 5-azido-2,3,4,6-tetra-O-benzyl-5-deoxy-D-glucononitrile and 2,3,4,6-tetra-O-benzyl-5-deoxy-5-trifluoroacetamido-D-glucononitrile starting from D-glucose are described.Unsuccessful attempts were made to convert these two compoun

Synthesis of the antibiotic 1,5-dideoxy-1,5-imino-D-glucitol; concomitant formation of the D-mannitol analogue

The easy accessible 1,2-O-isopropylidene-3-O-benzyl-α-D-glucofuranose was converted in six steps into 1,2-O-isopropylidene-3,6-di-O-benzyl-5-deoxy-5-azido-α-D-glucofuranose.The latter afforded, after acidolysis followed by hydrogenolysis, 1-deoxynojirimicine and a small quantity of 1-deoxymannonojirimicine.The antibiotic thus obtained had an inhibitory effect on the trimming of N-linked carbohydrates in IgM.