115351-17-2

Upstream product

• 18006-23-0 3,6-Di-O-benzyl-1,2-O-isopropylidene-β-L-ido-furanose 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 16958-26-2 1,2-O-isopropylidene-3,6-di-O-benzyl-5-azido-5-deoxy-α-D-glucofuranose 
• 19130-96-2 1,5-dideoxy-1,5-imino-D-glucitol 
• 127708-83-2 5-Azido-3,6-di-O-benzyl-5-deoxy-α/β-D-glucofuranose 
• 14199-63-4 1-deoxymannojirimycin 
• 128984-74-7 5-Amino-5-deoxy-3,6-di-O-benzyl-D-glucono-δ-lactam 
• 128984-73-6 5-azido-3,6-di-O-benzyl-5-deoxy-D-glucono-1,4-lactone 
• 14904-83-7 nojirimycin-δ-lactam 

Relevant academic research and scientific papers

SYNTHESIS OF DEOXYNOJIRIMYCIN AND OF NOJIRIMYCIN δ-LACTAM

The syntheses of nojirimycin δ-lactam and of deoxynojirimycin from a divergent ido-furanose intermediate are reported.

Synthesis of the antibiotic 1,5-dideoxy-1,5-imino-D-glucitol; concomitant formation of the D-mannitol analogue

The easy accessible 1,2-O-isopropylidene-3-O-benzyl-α-D-glucofuranose was converted in six steps into 1,2-O-isopropylidene-3,6-di-O-benzyl-5-deoxy-5-azido-α-D-glucofuranose.The latter afforded, after acidolysis followed by hydrogenolysis, 1-deoxynojirimicine and a small quantity of 1-deoxymannonojirimicine.The antibiotic thus obtained had an inhibitory effect on the trimming of N-linked carbohydrates in IgM.