14904-83-7

Basic information

• Product Name: 5-amino-5-deoxygluconic acid delta-lactam
• Synonyms: 5-amino-5-deoxygluconic acid delta-lactam
• CAS NO: 14904-83-7
• Molecular Formula: C6H11 N O5
• Molecular Weight: 177.16
• Mol File: 14904-83-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 500.6°C at 760 mmHg
• Flash Point: 256.6°C
• Appearance: /
• Density: 1.632g/cm³
• Vapor Pressure: 4.03E-12mmHg at 25°C
• Refractive Index: 1.608
• PKA: 11.88±0.70(Predicted)
• CAS DataBase Reference: 5-amino-5-deoxygluconic acid delta-lactam(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-5-deoxygluconic acid delta-lactam(14904-83-7)
• EPA Substance Registry System: 5-amino-5-deoxygluconic acid delta-lactam(14904-83-7)

Safety Data

• Hazardous Substances Data: 14904-83-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11NO5/c8-1-2-3(9)4(10)5(11)6(12)7-2/h2-5,8-11H,1H2,(H,7,12)/t2-,3-,4+,5-/m1/s1

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Relevant articles and documents

Investigations on the mechanism of glycoside splitting enzymes, VIII. Number of active sites of the β glucosidases A and B from sweet almond emulsin determined by fluorescence measurements

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COMPOSITIONS COMPRISING NB-DNJ, NE-DNJ OR D-GLUCARO-DELTA-LACTAM AND THEIR USES FOR THE TREATMENT OF PAIN AND OTHER NEUROLOGICAL CONDITIONS

Methods and compositions for the treatment of conditions including stress-associated, chronic pain, and neurodegenerative conditions in a mammal using a composition comprising NB-DNJ or a compound structurally similar thereto.

All eight stereoisomeric D-glyconic-δ-lactams: Synthesis, conformational analysis, and evaluation as glycosidase inhibitors

An efficient and general synthetic route to all eight stereoisomeric D-glycono-δ-lactams has been developed. The strategy involves, as a key step, a stereodivergent δ-lactam formation with configurational retention or inversion at C-4 of a starting γ-lactone to lead to two epimers of δ-lactam from one parent γ-lactone. Conformations of eight glycono-δ-lactams were examined by X-ray crystallographic analysis and molecular modeling. Analyses of conformation and glycosidase-inhibition provide useful information for the design of new glycosidase inhibitors.