1277185-70-2Relevant academic research and scientific papers
Synthesis of some pyrazole incorporated benzofurans and their antiinflammatory activity
Basawaraj, Raja,Chavan, Varsha,Patil, Ashok,Upendra,Gandhi, Narasimha,Noola, Shivanand,Vijaykumar,Naubade, Kashinath
, p. 129 - 132 (2013/09/23)
The reaction of 5-bromosalicylaldehyde 1 with hydroxylamine hydrochloride gave 5-bromosalicylonitrile 2 which upon condensation with ethyl chloroacetate followed by cyclization gave ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate 4. The compound 4 on treatment with hydrazine hydrate in ethanol gave 3-amino-5-bromo-1-benzofuran-2-carbohydrazide 5 which further on reaction with various substituted acetophenones in abs ethanol in presence of catalytic quantity of hydrochloric acid furnished corresponding hydrazones 6a-e. The title compounds 7a-e were synthesized by the reaction of 6a-e with Vilsmerier-Haack reagent. The structures of all synthesized compounds were established using analytical and spectral data. 6a-e and 7a-e have been evaluated for antiinflammatory activities.
