127725-15-9Relevant academic research and scientific papers
ENZYMATIC KINETIC RESOLUTION OF CYANOHYDRIN ACETATES AND ITS APPLICATION TO THE SYNTHESIS OF (S)-(-)-FRONTALIN
Ohta, Hiromichi,Kimura, Yoichi,Sugano, Yasushi,Sugai, Takeshi
, p. 5469 - 5476 (2007/10/02)
Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydrolyzed selectively the (R)-enantiomer, leving behind the (S)-enantiomer intact.The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-frontalin via unsaturated diol.
KINETIC RESOLUTION OF KETONE CYANOHYDRIN ACETATES WITH A MICROBIAL ENZYME
Ohta, Hiromichi,Kimura,Yoichi,Sugano, Yasushi
, p. 6957 - 6960 (2007/10/02)
Incubation of dl-1-cyano-1-metylalkyl (or alkenyl) acatates (methyl ketone cyanohydrin acetates) with cells of Pichia miso IAM 4682 afforded optically active acetates and the corresponding ketones via asymmetric hydrolysis.Resulting (S)-2-cyano-2-undecyl acetate was converted to the aminofuranone derivative without losing its optical purity.
