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127759-89-1

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127759-89-1 Usage

Description

Lobucavir is a nucleoside analog with potent antiviral properties, characterized by its pale pink solid appearance. It is primarily utilized in the medical field for the treatment of various viral infections, making it a valuable compound in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
Lobucavir is used as an antiviral agent for the treatment of viral infections caused by human immunodeficiency virus (HIV), cytomegalovirus (CMV), and herpes virus. Its effectiveness in combating these infections is attributed to its ability to interfere with the viral replication process, thereby limiting the spread of the virus and alleviating the symptoms associated with the infections.

Check Digit Verification of cas no

The CAS Registry Mumber 127759-89-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,7,5 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 127759-89:
(8*1)+(7*2)+(6*7)+(5*7)+(4*5)+(3*9)+(2*8)+(1*9)=171
171 % 10 = 1
So 127759-89-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m1/s1

127759-89-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Lobucavir

1.2 Other means of identification

Product number -
Other names 6H-Purin-6-one,2-amino-9-((1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127759-89-1 SDS

127759-89-1Related news

Regioselective enzymatic aminoacylation of Lobucavir (cas 127759-89-1) to give an intermediate for Lobucavir (cas 127759-89-1) prodrug08/10/2019

Synthesis of lobucavir prodrug, L-valine, [(1S,2R,3R)-3-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-(hydroxymethyl)cyclobutyl]methyl ester monohydrochloride (BMS 233866), requires regioselective coupling of one of the two hydroxyl groups of lobucavir (BMS 180194) with valine. Either hydroxyl gro...detailed

127759-89-1Relevant articles and documents

Regioselective coupling of tetraalkylammonium salts of 6-iodo-2-aminopurine to a cyclobutyl triflate: Efficient preparation of homochiral BMS-180,194, a potent antiviral carbocyclic nucleoside

Bisacchi,Singh,Godfrey Jr.,Kissick,Mitt,Malley,Di Marco,Gougoutas,Mueller,Zahler

, p. 2902 - 2905 (1995)

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Azetidinone derivatives for the treatment of HCMV infections

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, (2008/06/13)

A compound of formula 1: wherein Y is S or O; R1is C1-6alkyl; (C0-6alkyl)aryl; (C0-6alkyl)Het; or R1is an amino acid analog or dipeptide analog of the formula: wherein R2is H, C1-10alkyl; or an amide or ester group; A is C6-10aryl, Het or CH—R3wherein R3is C1-6alkyl or (C0-4alkyl)aryl; and Z is H, C1-6alkyl, or an acyl; R4is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; and R5is alkyl, cycloalkyl, carboxyl group; an aryl; Het or Het(lower alkyl); or R4and R5together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with phenyl or C(O)OCH2-phenyl, said phenyl ring optionally mono- or di-substituted with among others C(O)OR7wherein R7is lower alkyl or phenyl(lower alkyl); or a therapeutically acceptable acid addition salt thereof which compounds are useful in the treatment of HCMV infections.

Process for preparing substituted cyclobutane purines

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, (2008/06/13)

The present invention relates to a process for the preparation of substantially pure enantiomer of the purines substituted with cyclobutanes.

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