132178-73-5

Upstream product

• 132178-72-4 <1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 127696-10-0 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester 
• 132178-71-3 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid 

Downstream Products

• 132178-74-6 C₃₈H₆₀N₄O₈Si₂ 
• 132294-14-5 (1S-trans)-3,3-diethoxy-1,2-cyclobutanedimethanol 
• 132294-25-8 <1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 
• 132294-17-8 <(1S)-(1α,2β,3β)>-3-Hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 
• 127759-89-1 lobucavir 
• 132294-24-7 (2R-trans)-2,3-bis<(benzoyloxy)methyl>cyclobutanone 
• 132294-16-7 (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone 
• 132294-15-6 (1S-trans)-3,3-diethoxy-1,2-cyclobutanedimethanol dibenzoate ester 
• 132294-26-9 <1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester 
• 132294-18-9 <1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester 
• 132294-20-3 (1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine 
• 132294-28-1 <1S-(1α,2β,3α)>-6-amino-9-<2,3-bis(hydroxymethyl)cyclobutyl>purine 2,3-dibenzoate ester 
• 132294-19-0 <1S-(1α,2β,3α)>-3-<2-amino-6-(phenylmethoxy)-9H-purin-9-yl>-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 
• 132294-27-0 <1R-(1α,2β,3α)>-3-<2-amino-6-(phenylmethoxy)-9H-purin-9-yl>-1,2-cyclobutanedimethanol 1,2-dibenzoate ester 

Relevant academic research and scientific papers

Optically active cyclobutyl pyrimidine

The compound of the formula STR1 [1R-(1α(E),2β,3α)]-1-[2,3-bis(hydroxymethyl)cyclobutyl]-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione, is an antiviral agent that is active against herpes simplex virus 1 and varicella-zoster virus.

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues

The syntheses of the enantiomeric cyclobutyl guanine nucleoside analogues [1R-1α,2β,3α]- and [1S-1α,2β,3α]-2-amino-9-[2,3-bis(hydroxymethyl) cyclobutyl]-6H-purin-6-one (7 and 8, respectively) and the enantiomeric cyclobutyl adenine analogues [1R-1α,2β,3α]

Process for preparing an optically active cyclobutane nucleoside

A process for the preparation of the optically active compound [IR-(1α, 2β, 3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: STR1 and novel intermediates are described.