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Usage

Uses

Used in Pharmaceutical Applications:
(E)-3-(3,5-dihydroxyphenyl)acrylic acid is used as a pharmaceutical agent for its potential anti-inflammatory properties, which can help in reducing inflammation and pain associated with various conditions.
Used in Antiviral Applications:
In the field of antiviral research, (E)-3-(3,5-dihydroxyphenyl)acrylic acid is used as an antiviral agent to inhibit the replication and spread of certain viruses, potentially offering a therapeutic approach to viral infections.
Used in Anticancer Applications:
(E)-3-(3,5-dihydroxyphenyl)acrylic acid is used as an anticancer agent, where it may contribute to the inhibition of cancer cell growth and the modulation of cancer-related signaling pathways, thus offering a potential therapeutic strategy in cancer treatment.
Used in Nutraceutical Applications:
As a nutraceutical, (E)-3-(3,5-dihydroxyphenyl)acrylic acid is used as a dietary supplement for its antioxidant and potential health-promoting properties, supporting overall health and well-being.
Used in Food Industry:
In the food industry, (E)-3-(3,5-dihydroxyphenyl)acrylic acid is used as a natural preservative and flavor enhancer due to its antioxidant properties, which can help extend the shelf life of various food products and improve their taste.
Used in Cosmetic Applications:
(E)-3-(3,5-dihydroxyphenyl)acrylic acid is used in the cosmetic industry for its antioxidant and anti-inflammatory properties, which can be beneficial in skincare products for promoting healthy and radiant skin.

Upstream product

• 20767-04-8 (E)-3,5-dimethoxycinnamic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 141-82-2 malonic acid 
• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 39192-49-9 3,5-diacetoxybenzoyl chloride 

Downstream Products

• 16909-11-8 3-(3,5-dimethoxyphenyl)acrylic acid 

Relevant academic research and scientific papers

Br?nsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio-Catechol

An efficient conversion of biorenewable ferulic acid into bio-catechol has been developed. The transformation comprises two consecutive defunctionalizations of the substrate, that is, C?O (demethylation) and C?C (de-2-carboxyvinylation) bond cleavage, occurring in one step. The process only requires heating of ferulic acid with HCl (or H2SO4) as catalyst in pressurized hot water (250 °C, 50 bar N2). The versatility is shown on a variety of other (biorenewable) substrates yielding up to 84 % di- (catechol, resorcinol, hydroquinone) and trihydroxybenzenes (pyrogallol, hydroxyquinol), in most cases just requiring simple extraction as work-up.

Semi-synthesis and Structure–Activity Relationship of Neuritogenic Oleanene Derivatives

(3S,4R)-23,28-Dihydroxyolean-12-en-3-yl (2E)-3-(3,4-dihydroxyphenyl)acrylate (1 a), which possesses significant neuritogenic activity, was isolated from the traditional Chinese medicine (TCM) plant, Desmodium sambuense. To confirm the structure and to assess biological activity, we semi-synthesized 1 a from commercially available oleanolic acid. A series of novel 1 a derivatives was then designed and synthesized for a structure–activity relationship (SAR) study. All synthetic derivatives were characterized by analysis of spectral data, and their neuritogenic activities were evaluated in assays with PC12 cells. The SAR results indicate that the number and position of the hydroxy groups on the phenyl ring and the triterpene moiety, as well as the length of the (saturated or unsaturated) alkyl chain that links the phenyl ring with the triterpene critically influence neuritogenic activity. Among all the tested compounds, 1 e [(3S,4R)-23,28-dihydroxyolean-12-en-3-yl (2E)-3-(3,4,5-trihydroxyphenyl)acrylate] was found to be the most potent, inducing significant neurite outgrowth at 1 μm.

Second bioluminescence-activating component in the luminous fungus Mycena chlorophos

Mycena chlorophos is an oxygen-dependent bioluminescent fungus. The mechanisms underlying its light emission are unknown. A component that increased the bioluminescence intensity of the immature living gills of M. chlorophos was isolated from mature M. chlorophos gills and chemically characterized. The bioluminescence-activating component was found to be trans-3,4-dihydroxycinnamic acid and its bioluminescence activation was highly structure-specific. 13C- and 18O-labelling studies using the immature living gills showed that trans-3,4-dihydroxycinnamic acid was synthesized from trans-4-hydroxycinnamic acid in the gills by hydroxylation with molecular oxygen as well as by the general metabolism, and trans-3,4-dihydroxycinnamic acid did not produce hispidin (detection-limit concentration: 10 pmol/1 g wet gill). Addition of 0.01 mM hispidin to the immature living gills generated no bioluminescence activation. These results suggested that the prompt bioluminescence activation resulting from addition of trans-3,4-dihydroxycinnamic acid could not be attributed to the generation of hispidin. Copyright