127822-76-8

Upstream product

• 127822-76-8 (+/-)-erythro-β-chloro-γ-hydroxy-1-triphenylmethyl-1H-4-imidazolepropanamine 
• 132553-76-5 [(2R,3S)-2-Chloro-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 132553-77-6 [2-Chloro-3-oxo-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 132553-76-5 [(2S,3S)-2-Chloro-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 131120-95-1 N-<3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl>-trichloroacetamide trans 
• 127798-61-2 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol 

Downstream Products

• 132553-76-5 [(2R,3S)-2-Chloro-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 110883-46-0 (+/-)-threo-2-amino-β-chloro-γ-hydroxy-1H-4-imidazolepropanamine 
• 132553-74-3 {(2S,3S)-2-Chloro-3-[2-(4-chloro-phenylazo)-1H-imidazol-4-yl]-3-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 132553-77-6 [2-Chloro-3-oxo-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127822-76-8 (1S,2S)-3-Amino-2-chloro-1-(1-trityl-1H-imidazol-4-yl)-propan-1-ol 
• 134822-16-5 (5S,6S)-5-Chloro-6-(1-trityl-1H-imidazol-4-yl)-[1,3]oxazinan-2-one 
• 132553-76-5 [(2S,3S)-2-Chloro-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 134822-16-5 (5R,6S)-5-Chloro-6-(1-trityl-1H-imidazol-4-yl)-[1,3]oxazinan-2-one 

Relevant academic research and scientific papers

A diastereoselective synthesis of girolline

Girolline (RP 49532, 1), a new antitumour agent, was prepared in the racemic series using an oxidation-reduction sequence starting from (±)-erythro-β-chloro-γ-hydroxy- 1-triphenylmethyl-1H-4-imidazolepropanamine 3. The heterocyclic amino function was intr

DIASTEREOSELECTIVE CHLOROCYCLOFUNCTIONALIZATION OF N-ALLYLIC TRICHLOROACETAMIDES: SYNTHESIS OF AN ANALOGUE AND POTENTIAL PRECURSOR OF RP49532

Treatment of (E)-N-cinnamyl trichloroacetamide with hypochlorous acid yielded trans-dihydro-oxazine 8 which was easily hydrolyzed to (+/-)-erythro-β-chloro-γ-hydroxy-γ-phenyl-propanamine 2.Applied to the imidazole series, this chlorocyclization gave 15, a