127798-61-2

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 3034-50-2 5-imidazolecarboxaldehyde 
• 76-83-5 trityl chloride 
• 33769-07-2 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 107-02-8 acrolein 

Downstream Products

• 131120-99-5 2,2,2-Trichloro-N-[5-prop-2-en-(E)-ylidene-3-trityl-4,5-dihydro-3H-imidazol-4-yl]-acetamide 
• 127798-62-3 4-[1-(tert-Butyl-dimethyl-silanyloxy)-allyl]-1-trityl-1H-imidazole 
• 131120-95-1 N-<3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl>-trichloroacetamide trans 
• 272438-83-2 1-(1-trityl-1H-imidazol-4-yl)-propen-1-one 
• 127822-76-8 (+/-)-erythro-β-chloro-γ-hydroxy-1-triphenylmethyl-1H-4-imidazolepropanamine 
• 131121-00-1 2,2,2-Trichloro-N-[1-(1-trityl-1H-imidazol-4-yl)-allyl]-acetamide 
• 131120-96-2 (5S,6R)-5-Chloro-2-trichloromethyl-6-(1-trityl-1H-imidazol-4-yl)-5,6-dihydro-4H-[1,3]oxazine 
• 127798-64-5 Acetic acid 1-(tert-butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxy)-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester 
• 127798-64-5 Acetic acid 1-(tert-butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxy)-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester 
• 127798-66-7 [3-(tert-Butyl-dimethyl-silanyloxy)-2-chloro-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-66-7 [3-(tert-Butyl-dimethyl-silanyloxy)-2-chloro-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-63-4 [3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-63-4 [3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-69-0 3-Amino-1-[2-(4-bromo-phenylazo)-1H-imidazol-4-yl]-2-chloro-propan-1-ol 

Relevant academic research and scientific papers

COMPOUND, COMPOSITIONS, AND METHODS

Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Synthesis of natural 1-amidopyrrolizidines, absouline and laburnamine, derivatives and aminopyrrolidinoimidazole analogues

Natural 1-amidopyrrolizidines, absouline and laburnamine, were synthesized via stable pyrrolizidin-1-one hydrobromide. Amides, ester derivatives and aminopyrrolidinoimidazole analogues were also prepared and their biological activities tested. (C) 2000 Elsevier Science Ltd.

A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds

Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.

DIASTEREOSELECTIVE CHLOROCYCLOFUNCTIONALIZATION OF N-ALLYLIC TRICHLOROACETAMIDES: SYNTHESIS OF AN ANALOGUE AND POTENTIAL PRECURSOR OF RP49532

Treatment of (E)-N-cinnamyl trichloroacetamide with hypochlorous acid yielded trans-dihydro-oxazine 8 which was easily hydrolyzed to (+/-)-erythro-β-chloro-γ-hydroxy-γ-phenyl-propanamine 2.Applied to the imidazole series, this chlorocyclization gave 15, a

PREMIERE SYNTHESE TOTALE DE GIROLLINE

Isolated from a Sponge, girolline is an 2-amino imidazole derivative with significant antitumoral activity.Its total synthesis is described for the first time in this communication.