127861-30-7

Basic information

• Product Name: METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE
• Synonyms: METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE;Methyl 2-Chloro-6-Methoxypyrimidine-4-Carboxylate(WX636148)
• CAS NO: 127861-30-7
• Molecular Formula: C₇H₇ClN₂O₃
• Molecular Weight: 202.6
• Mol File: 127861-30-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE(127861-30-7)
• EPA Substance Registry System: METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE(127861-30-7)

Safety Data

• Hazardous Substances Data: 127861-30-7(Hazardous Substances Data)

Usage

Description

METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE is a pyrimidine derivative with the molecular formula C7H7ClN2O4. It features a chlorine atom and a methoxy group attached to the pyrimidine ring, along with a carboxylate group. This chemical compound is utilized as an intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE is used as an intermediate for the synthesis of new drugs. Its unique structure and reactivity make it a valuable component in the development of pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE serves as an intermediate in the production of crop protection products. Its role in the synthesis of agrochemicals contributes to the development of effective solutions for pest and disease control in agriculture.
Used in Organic Synthesis:
METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE is used as a building block in organic synthesis. Its versatile structure allows it to be incorporated into a wide range of organic compounds, facilitating the creation of new molecules with various applications.
Used in Chemical Research:
METHYL 2-CHLORO-6-METHOXYPYRIMIDINE-4-CARBOXYLATE is also utilized in chemical research, where it can be employed to study the properties and reactions of pyrimidine derivatives. Its unique structure provides opportunities for exploring new chemical reactions and mechanisms.

Upstream product

• 67-56-1 methanol 
• 6299-85-0 2,6-dichloropyrimidine-4-carboxylic acid methyl ester 
• 124-41-4 sodium methylate 

Downstream Products

• 1312663-66-3 Methyl 2-(4-(((tert-butoxycarbonyl)amino)methyl)piperidin-1-yl)-6-methoxypyrimidine-4-carboxylate 
• 1312663-67-4 tert-Butyl ((1-(4-formyl-6-methoxypyrimidin-2-yl)piperidin-4-yl)methyl)carbamate 
• 1312662-65-9 (Z)-5-((6-methoxy-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione 
• 1244017-09-1 butyl 2-anilino-6-chloropyrimidine-4-carboxylate 
• 1244017-08-0 n-butyl 6-hydroxy-2-(phenylamino)pyrimidine-4-carboxylate 

Relevant articles and documents

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb suggested a novel mechanism of action. The compounds were bactericidal against replicating Mtb and retained potency against clinical isolates of Mtb. Although selected MmpL3 mutant strains of Mtb showed resistance to these compounds, there was no shift in the minimum inhibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible resistance mechanism for the compounds but not necessarily as the target. RNA transcriptional profiling and the checkerboard board 2D-MIC assay in the presence of varying concentrations of ferrous salt indicated perturbation of the Fe-homeostasis by the compounds. Structure-activity relationship studies identified potent compounds with good physicochemical properties and in vitro microsomal metabolic stability with moderate selectivity over cytotoxicity against mammalian cell lines.

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.