127878-51-7

Basic information

• Product Name: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate
• Synonyms: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate
• CAS NO: 127878-51-7
• Molecular Weight: 265.357
• Mol File: 127878-51-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate(127878-51-7)
• EPA Substance Registry System: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate(127878-51-7)

Safety Data

• Hazardous Substances Data: 127878-51-7(Hazardous Substances Data)

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 15922-79-9 O-Acetyl N-hydroxy-2-thiopyridone 
• 149419-62-5 seleno-(2-pyridyl) p-tolueneselenosulfonate 
• 144432-93-9 Dithiocarbonic acid O-[1-hexyl-2-(toluene-4-sulfonyl)-nonyl] ester S-methyl ester 
• 4545-20-4 benzophenone tosylhydrazone 
• 17697-12-0 benzeneseleninic anhydride 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 1424-52-8 p-tolylsulfonyl isothiocyanate 
• 91233-19-1 1-(adamantane-1-carbonyloxy)pyridine-2(1H)-thione 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 28519-50-8 potassium thiotosylate 

Downstream Products

• 2637-35-6 2-thiocyanatopyridine 
• 19294-29-2 potassium 4-methylbenzenesulfinate 

Relevant articles and documents

Nickel-Catalyzed Difunctionalization of Alkynyl Bromides with Thiosulfonates and N -Arylthio Succinimides: A Convenient Synthesis of 1,2-Thiosulfonylethenes and 1,1-Dithioethenes

An efficient nickel-catalyzed vicinal thiosulfonylation of 1-bromoalkynes with thiosulfonates in the presence of cesium carbonate is described. An operationally simple and highly regioselective atom transfer radical addition (ATRA) of alkynyl bromides provides a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields. The extensive substrate scope of both alkynyl bromides and thiosulfonates is explored with a broad range of functional groups. Indole-derived 1,1-bromoalkenes were also successfully explored in this 1,2-thiosulfonylation process. Moreover, the nickel-catalyzed geminal -dithiolation of alkynyl bromides with N -arylthio succinimides provides 1,1-dithioalkenes in high yields. The present protocol is reliable on gram scale, and a sequential one-pot bromination and thiosulfonylation of phenylacetylene is achieved in a scale-up synthesis. Following control experiments, a plausible mechanism is proposed to rationalize the experimental outcome and the vicinal thio-sulfonylation.

PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.

MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBSTITUENT AT 14-POSITION

To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.