127903-20-2

Basic information

• Product Name: 6-(FMOC-AMINO)-1-HEXANOL
• Synonyms: (9H-fluoren-9-yl)Methyl (6-hydroxyhexyl)carbaMate;6-Fmoc-Acp-OL;Fmoc-Acp-OL;6-(Fmoc-amino)-1-hexanol≥ 98% (HPLC);FMOC-ACP(6)OL;FMOC-6-AMINOHEXANOL;FMOC-NH-(CH2)6-OH;6-(FMOC-AMINO)-1-HEXANOL
• CAS NO: 127903-20-2
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.43
• Mol File: 127903-20-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 119 °C
• Boiling Point: 539.2 °C at 760 mmHg
• Flash Point: 279.9 °C
• Appearance: /
• Density: 1.151 g/cm³
• Vapor Pressure: 1.86E-12mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• BRN: 4531101
• CAS DataBase Reference: 6-(FMOC-AMINO)-1-HEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(FMOC-AMINO)-1-HEXANOL(127903-20-2)
• EPA Substance Registry System: 6-(FMOC-AMINO)-1-HEXANOL(127903-20-2)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• WGK Germany: 3
• Hazardous Substances Data: 127903-20-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Reagent for the introduction of a spacer arm

InChI:InChI=1/C21H25NO3/c23-14-8-2-1-7-13-22-21(24)25-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20/h3-6,9-12,20,23H,1-2,7-8,13-15H2,(H,22,24)

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 629-11-8 1,6-hexanediol 
• 742103-41-9 6-[(4-methoxy-phenyl)-diphenyl-methoxy]-hexan-1-ol 
• 88574-06-5 6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid 
• 1308344-03-7 (9H-fluoren-9-yl)methyl (6-((4-methoxybenzyl)oxy)hexyl)carbamate 
• 1308344-14-0 C₁₄H₂₃NO₂ 

Downstream Products

• 290308-58-6 Succinic acid benzyl ester (2R,3R,4R,5R,6R)-3,4-diacetoxy-5-acetylamino-6-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexyloxy]-tetrahydro-pyran-2-ylmethyl ester 
• 952661-18-6 2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid 
• 952661-13-1 2-benzyl-3-[{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}(hydroxy)phosphoryl]propanoic acid 
• 134939-08-5 VO(OCH₂CH(CH₃)2)2(OC₆H₄NH₂) 

Relevant articles and documents

A facile synthesis of ω-aminoalkyl ammonium hydrogen phosphates

A series of ω-aminoalkyl ammonium hydrogen phosphates were synthesized through a simple and efficient three-step method. The starting materials, ω-aminoalkyl alcohols (AC-n, with carbon number n = 3, 4, 5, 6), were amino-protected with 9-fluorenylmethyl chloroformate (Fmoc-Cl), followed by phosphorylation with POCl3 and deprotection in piperidine/DMF. The structures of each intermediate and final product were confirmed by 1H NMR, FTIR and mass spectrum. The yield of each step was about 77-92%, with a total yield higher than 56%. This new method was superior in low-cost raw materials, mild reaction temperatures (0-25°C) and easy purification methods.

Preparation method of triphosphate compound and deoxynucleotide

The invention discloses a preparation method of a triphosphate compound and deoxynucleotide. In the preparation method of the triphosphate compound, tetrahydrofuran is used for replacing trimethyl phosphate/triethyl phosphate, tri-n-propylamine is used for replacing tri-n-butylamine, and acetonitrile is used for replacing N,N-dimethylformamide; so that the preparation method has the advantages that the yield is high, few byproducts are produced, a solvent is easy to remove, and the triphosphate compound is non-toxic, safe and the like. According to the preparation method of the deoxynucleotide, the morpholine dimethylformamide solution is used for replacing a triethylamine solution to remove the F-moc group, so that the reaction time is greatly shortened, the generation of byproducts is reduced, and the yield is improved.

Extracellular targeted drug conjugates

The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.