1279030-48-6

Basic information

• Product Name: (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid
• Synonyms: (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid;D-Proline, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4S)-;(4S)-4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-D-PROLINE
• CAS NO: 1279030-48-6
• Molecular Formula: C10H18N2O4
• Molecular Weight: 230.26092
• Mol File: 1279030-48-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid(1279030-48-6)
• EPA Substance Registry System: (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid(1279030-48-6)

Safety Data

• Hazardous Substances Data: 1279030-48-6(Hazardous Substances Data)

Usage

General Description

(2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid is a chemical compound with the molecular formula C11H20N2O4. It is an amino acid derivative with a pyrrolidine ring and a carboxylic acid functional group. The compound features a tert-butoxy carbonyl protecting group, which is often used to block reactive functional groups during chemical reactions. (2R,4S)-4-{[(tert-butoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid may be used in organic synthesis as a building block for the preparation of more complex molecules, or as a research tool in biochemical studies. It is important to handle and use this compound with care, following proper safety protocols and guidelines.

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 178488-33-0 (2R,4R)-4-Methanesulfonyloxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 489446-81-3 (2R,4S)-4-tert-Butoxycarbonylamino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 739360-84-0 (2R,4S)-1-benzyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 2584-71-6 cis-hydroxy-D-proline 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 329191-66-4 (2S,4R)-N^α-Cbz-4-aminoproline benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 853063-25-9 (2S,4R)-N^α-Cbz-4-N-Boc-aminoproline benzyl ester 
• 281666-43-1 4-amino-N-benzyloxycarbonyl-L-cis-proline 
• 329191-57-3 (2S,4S)-N^α-Cbz-4-aminoproline benzyl ester 
• 853063-23-7 (2S,4S)-N^α-Cbz-4-N-Boc-aminoproline benzyl ester 
• 281666-44-2 4-N-tert-butyloxycarbonylamino-N-benzyloxycarbonyl-L-cis-proline 

Downstream Products

• 1253790-74-7 4S-N⁴(t-Boc)-N₁(Fmoc)-D-amino proline 

Relevant articles and documents

Novel μ opioid antagonists derived from the μ opioid agonists endomorphin and [Dmt1]DALDA (H-Dmt-D-Arg-Phe-Lys-NH2)

Hybrid analogues of the μ opioid agonists endomorphin and [Dmt1]DALDA (H-Dmt-D-Arg-Phe-Lys-NH2, Dmt?=?2′,6′-dimethyltyrosine) containing cis-4-amino-Pro, trans-4-amino-Pro, cis-4-aminoethyl-Pro or cis-4-guanidinylethyl-Pro in the 2 p

Site-directed spin labeling of a collagen mimetic peptide

At every turn: Electron paramagnetic resonance spectroscopy was used to investigate the dynamics of triple helix folding/unfolding of host-guest collagen mimetic peptide with a spin-labeled central triplet in Ac-(Gly-Pro-Hyp)7-Gly-Gly-NH2 (see figure). Copyright

Synthesis of alanine and proline amino acids with amino or guanidinium substitution on the side chain

Competitive binding of peptides containing basic amino acids to disrupt or prevent the Tat-TAR interaction could result in diminished transcription as well as translation and hence constitutes an alternative way of controlling HIV replication. Therefore, we synthesized guanidinium and amino containing amino acids, based on a proline or an alanine scaffold. The introduction of the guanidinium moiety was best accomplished using 1H- pyrazole-1-carboxamidine hydrochloride, with Pmc used for its protection. The absence of racemization, maintained throughout the whole synthesis, was confirmed by chiral purity determination. These building blocks were smoothly incorporated into oligopeptides, which proved their suitability for use in a combinatorial approach for selecting TAR binding ligands. (C) 2000 Elsevier Science Ltd.