127905-83-3

Basic information

• Product Name: N-{2-[(4-methoxyphenyl)sulfanyl]benzyl}-N-methylamine
• Synonyms: N-{2-[(4-methoxyphenyl)sulfanyl]benzyl}-N-methylamine
• CAS NO: 127905-83-3
• Molecular Formula: C₁₅H₁₇NOS
• Molecular Weight: 259.36658
• Mol File: 127905-83-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{2-[(4-methoxyphenyl)sulfanyl]benzyl}-N-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[(4-methoxyphenyl)sulfanyl]benzyl}-N-methylamine(127905-83-3)
• EPA Substance Registry System: N-{2-[(4-methoxyphenyl)sulfanyl]benzyl}-N-methylamine(127905-83-3)

Safety Data

• Hazardous Substances Data: 127905-83-3(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 128958-99-6 1-(2-(4-methoxyphenylthio)phenyl)-2-propylamine 
• 127905-51-5 2-(N-methylcarbamoyl)phenyl 4-methoxyphenyl sulfide 
• 128959-02-4 N-(1-(2-(4-methoxyphenylthio)phenyl)-2-propyl)formamide 
• 89-98-5 2-chloro-benzaldehyde 
• 128958-93-0 1-(2-(4-methoxyphenylthio)phenyl)-2-nitropropene 
• 128958-85-0 2-(4-methoxyphenylthio)benzaldehyde 
• 43183-12-6 2-(4-Methoxyphenylthio)benzoyl chloride 
• 19862-91-0 2-<(4-methoxyphenyl)thio>benzoic acid 
• 696-63-9 4-Methoxybenzenethiol 

Downstream Products

• 127906-34-7 4-(2-Methylaminomethyl-phenylsulfanyl)-phenol 

Relevant articles and documents

POTENTIAL ANTIDEPRESSANTS: 1-(2-(METHOXY- AND HYDROXY-PHENYLTHIO)PHENYL)-2-PROPYLAMINES

2-(Methoxyphenylthio)benzaldehydes Xa-Xd were reacted with nitroethane in boiling acetic acid to give the corresponding 1-aryl-2-nitropropenes XIIa-XIId: benzonitriles XIIIa and XIIIc and benzaldoximes XXIc and XXId were isolated as by-products.Chromatogr

POTENTIAL ANTIDEPRESSANTS: 2-(METHOXY- AND HYDROXY-PHENYLTHIO)BENZYLAMINES AS SELECTIVE INHIBITORS OF 5-HYDROXYTRYPTAMINE RE-UPTAKE IN THE BRAIN

2-, 3- and 4-Methoxythiophenol, and 2,4-, 2,5- and 3,4-dimethoxythiophenol were transformed in two steps to the corresponding 2-(methoxyphenylthio)benzoyl chlorides XIII which were reacted with ammonia, methylamine, dimethylamine, diethylamine, dipropylamine, and di(2-propyl)amine to give the amides XIV-XIX.These were reduced mostly with lithium aluminium hydride to the amines II-VII.These methoxylated amines were demethylated mostly either by heating with pyridine hydrochloride or by treatment with boron tribromide.Some of the 2-(methoxy- and hydroxy-phenylthio)benzylamines prepared, especially compounds II, III, XXI, and XXII, indicated properties of potential antidepressants being highly active and selective inhibitors of 5-hydroxytryptamine re-uptake in the brain structures and having the typical antireserpine activity.The most interesting compound of the series is XXIb (hydrogen maleate VUFB-15 468) which is undergoing preclinical studies.On the basis of its structure, some further compounds (XXVII-XXIX, XXXIX-XLI) were prepared by various methods.