127912-58-7

Basic information

• Product Name: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol
• Synonyms: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol;(R)-1-(6-Bromopyridin-2-yl)-2,2-dimethylpropan-1-ol
• CAS NO: 127912-58-7
• Molecular Weight: 244.131
• Mol File: 127912-58-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol(127912-58-7)
• EPA Substance Registry System: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol(127912-58-7)

Safety Data

• Hazardous Substances Data: 127912-58-7(Hazardous Substances Data)

Upstream product

• 127127-27-9 (rac)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol 
• 127049-48-3 1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one 
• 598-98-1 Methyl pivalate 

Downstream Products

• 127049-50-7 (R,R)-6,6'-bis-(1-hydroxy-2,2-dimethylpropyl)-2,2'-bipyridine 
• 138982-99-7 (R)-2,2-dimethyl-1-(6-phenyl-pyridin-2-yl)propanol 

Relevant articles and documents

Optically pure bulky (hetero)arylalkyl carbinols via kinetic resolution

Planar chiral nucleophilic catalyst Fc-PIP was employed in the kinetic resolution of bulky (hetero)arylalkyl carbinols delivering unreacted alcohols with extremely high enantiomeric excess (>99.0% ees) in ideal conversions ranging from 50.4-56.7%.

Enantioselective Synthesis of Optically Active Pyridine Derivatives and C2-Symmetric 2,2'-Bipyridines

Optically active pyridine derivatives 2, 15, 18, 19, 21, 26, and 27 are obtained by enantioselective reduction of the corresponding ketones 5, 7, 11-13, 24, and 25 using the chiral borane reagent chlorodiisopinocampherylborane .Nickel(0)-mediated coupling of bromopyridines 2, 15, and 31 gives C2-symmetric 2,2'-bipyridines (R,R)-32, (R,R)-33, and (S,S)-38, respectively, which form metal complexex with Co(II), Pd(II), Cu(I), and Ag(I).Aryl-substituted pyridines 26, and 39-41 are synthesized by palladium(0)-catalized cross coupling of 2 and 15 with boronic acids 42-44.Key Words: 2,2-Bipyridines / Pyridines, optically active / Chiral ligands / Asymmetric Synthesis / Catalysis, enantioselective