138982-99-7

Upstream product

• 139042-67-4 1-(6-phenylpyridin-2-yl)-2,2-dimethylpropan-1-one 
• 127912-58-7 (R)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropanol 
• 98-80-6 phenylboronic acid 
• 598-98-1 Methyl pivalate 
• 127049-48-3 1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one 
• 630-19-3 pivalaldehyde 
• 139163-57-8 rac-2,2-dimethyl-1-(6-phenyl-pyridin-2-yl)propanol 
• 127127-27-9 (rac)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol 
• 630-18-2 tert-butyl isocyanide 

Relevant academic research and scientific papers

ASYMMETRIC AMPLIFICATION IN NICKEL-CATALYZED CONJUGATE ADDITION TO CHALCONE

Nickel complexes with optically active pyridine ligands catalyze the conjugate addition of diethyl zinc to chalcone.This catalytic alkylation gives products with ee's of up to 86percent.Strong asymmetric amplification has been observed using ligands of lo

Enantioselective Synthesis of Optically Active Pyridine Derivatives and C2-Symmetric 2,2'-Bipyridines

Optically active pyridine derivatives 2, 15, 18, 19, 21, 26, and 27 are obtained by enantioselective reduction of the corresponding ketones 5, 7, 11-13, 24, and 25 using the chiral borane reagent chlorodiisopinocampherylborane .Nickel(0)-mediated coupling of bromopyridines 2, 15, and 31 gives C2-symmetric 2,2'-bipyridines (R,R)-32, (R,R)-33, and (S,S)-38, respectively, which form metal complexex with Co(II), Pd(II), Cu(I), and Ag(I).Aryl-substituted pyridines 26, and 39-41 are synthesized by palladium(0)-catalized cross coupling of 2 and 15 with boronic acids 42-44.Key Words: 2,2-Bipyridines / Pyridines, optically active / Chiral ligands / Asymmetric Synthesis / Catalysis, enantioselective