127916-08-9

Upstream product

• 79-37-8 oxalyl dichloride 
• 326818-17-1 1-(3-Methyl-5-phenyl-isoxazol-4-yl)-ethanol 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 141-78-6 ethyl acetate 
• 598-49-2 N-chloroacetamide 
• 1817-57-8 4-phenyl-3-butyne-2-one 

Downstream Products

• 1585971-18-1 C₂₄H₂₆F₂N₂O₃S 
• 127916-10-3 1-(3,5-Dimethyl-isoxazol-4-yl)-1-phenyl-ethane-1,2-diol 
• 127916-12-5 1-(2-methyl-5-phenyloxazol-4-yl)ethan-1-one 
• 31301-47-0 (3,5-dimethylisoxazol-4-yl)(phenyl)methanone 
• 127916-16-9 2-acetyl-2-benzoyl-3-methyl-2H-azirine 

Relevant academic research and scientific papers

Transformation of 1,2,3,7a-tetrahydroimidazo[1,2-b]isoxazole derivatives into isoxazoles

The reactions of 1,2,3,7a-tetrahydroimidazo[1,2-b]isoxazole derivatives with electrophilic reagents, such as protic acids, benzoyl chloride, BF 3, and bromine, produce isoxazole, 2,2,3,3-tetramethylaziridine, and 2,3,3-trimethylpropen-2-ylamine

Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases

The present invention provides compounds of formula I: 1where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Comparative Reactivity of 3-Methyl-5-phenylisoxazole and 3-Methyl-5-Phenylisothiazole Against Electrophilic Compounds

A comparative study of reactions of 3-methyl-5-phenylisoxazole and 3-methyl-5-phenylisothiazole with electrophilic compounds in the presence of n-BuLi, LICA or LICA-TMEDA is reported.By using LICA-TMEDA, regioselective reactions of heterocyclic compounds at the C-3 methyl group are obtained.With n-BuLi or LICA and the isoxazole derivative a product mixture at the C-4 position and the C-3 methyl group is found.In the case of isothiazole compound, only with methyl iodide and n-BuLi, the dialkylated product at both positions is formed.

Photochemistry of 4-Acylisoxazoles

The photochemistry of 4-acylisoxazoles 4, 5, 13, 14, and 17 was investigated in an effort to clarify literature contradictions and anomalies and to provide a more detailed picture of the nature and number of intermediates involved in photoreactions of these systems.In contrast to a previous report on the photorearrangement of 14, both oxazoles expected from a 2H-azirine intermediate have been observed.Wavelength studies of 5 and the derived 2H-azirine 10 revealed evidence for the involvement of at least two distinct product-forming intermediates.The results of quantum yield and laser photolysis measurements for ketones 4, 14, and 17 have been interpreted in terms of rapid openings of triplet states to form diradical-like intermediates coupled with efficient reclosures (70-99percent).