127956-55-2

Upstream product

• 22105-07-3 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)propan-1-one 
• 109-94-4 formic acid ethyl ester 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 104-88-1 4-chlorobenzaldehyde 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 52923-39-4 (E)-2'-hydroxy-4-chlorochalcone 

Downstream Products

• 346434-41-1 (E)-3-(4-chlorobenzylidene)-2,3-dihydro-2-fluorochroman-4-one 
• 346467-43-4 3-(α-bromo-4-chlorobenzyl)chromone 

Relevant academic research and scientific papers

Electrolytic partial flourination of organic compounds. 55. Highly regio- and stereoselective anodic monoflourination of 2,3-dihydrochroman-4-one and chromone derivatives

Anodic monoflourination at the position α to the oxygen atom of the (E)-3-benylidene-2,3-dihydrochroman-4-one derivatives was successfully carried out to provide the corresponding 2-flourochromanones selectively. This is the first regioselective electrochemical flourination of fused-type, oxygen-containing heterocyclic compounds. Anodic flourination of a chromone derivative also gave a similar flourinated chromanone stereoselectively.

New convenient synthesis of homoisoflavanones and (±)-di-O- methyldihydroeucomin

Upon reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (2′-hydroxydihydrochalcones) with dimethylaminodimethoxymethane in boiling toluene, the corresponding 3-benzylchromones are obtained in excellent yields. These latter lead to 3-benzylchroman-4-on

Reactivity of α-arylidene benzoheteracyclanone dibromides toward azide ion: An effective approach to 3-(α-substituted-benzyl)chromones and -1-thiochromones

Treatment of dibromides of 3-arylidenechromanones and -1-thiochromanones with sodium azide resulted in the formation of 3-(α-azidobenzyl)chromones and -1-thiochromones whereas dibromides having no antiperiplanar vicinal hydrogen in the ring such as flavanone, 1-thioflavanone and benzosuberone derivatives afforded only the parent enones by bromine elimination. Evidence supported the intermediacy of 3-(α-bromobenzyl)chromones and -1-thiochromones in this reaction. These postulated intermediates were prepared in an independent way and transformed into azides in high yield.

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective