22105-07-3

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanone, 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)is used as an analgesic for its pain-relieving properties, particularly in conditions that involve inflammation such as arthritis, menstrual cramps, and minor injuries like sprains and strains.
Used in Anti-inflammatory Applications:
Ketoprofen is utilized as an anti-inflammatory agent to reduce inflammation and associated discomfort, making it suitable for a range of inflammatory conditions.
Used in Fever Reduction:
1-Propanone, 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)is also used as an antipyretic to lower fever by reducing the body's temperature in response to illness or injury.
It is important to follow the directions provided by a healthcare professional when using ketoprofen to ensure safe and effective treatment while minimizing the risk of potential side effects. The drug is available in various forms, including tablets, capsules, and topical creams, catering to different administration preferences and needs.

Upstream product

• 3033-96-3 4-chloro-2'-hydroxychalcone 
• 118-93-4 o-hydroxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 52923-39-4 (E)-2'-hydroxy-4-chlorochalcone 

Downstream Products

• 94141-40-9 (+/-)-3-(4'-chlorobenzyl)-3-hydroxymethyl-2,3-dihydro-4H-1-benzopyran-4-one 
• 127956-55-2 3-(4-chlorobenzyl)chromone 
• 76285-74-0 3-(4-chlorobenzyl)-chroman-4-one 
• 93514-36-4 4'-chloroflavanone 
• 10420-75-4 4'-chloroflavone 

Relevant academic research and scientific papers

Solvent-Controlled Hydrogenation of 2’-Hydroxychalcones: A Simple Solution to the Total Synthesis of Bussealins

A solvent-controlled hydrogenation of 2’-hydroxychalcones to selectively obtain different hydrogenation products is herein reported. Thus, hydrogenation of 2’-hydroxychalcones using EtOH as solvent provided the corresponding 1,3-diarylpropanes in excellent yields. On the contrary, when the hydrogenation was performed in DCM, the corresponding dihydrochalcones were isolated. Switching the reaction solvent to n-BuOH/H2O (1:1), afforded 1,3-diarylpropanols from moderate to good yields. The methodology here reported offers a straightforward, simple and cost-effective method for the preparation of a wide variety of 2’-hydroxy-1,3-diarylpropanes derivatives, and was also applied to the preparation of natural Bussealins C and D. (Figure presented.).

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones

Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3- dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by 1H NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c.

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective