127958-64-9

Usage

Uses

Used in Pharmaceutical Industry:
Hexahydro-2H-benzo[b][1,4]oxazin-3(4H)-one is used as an intermediate in the synthesis of various drugs for its ability to contribute to the formation of complex molecular structures. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals.
Used in Organic Synthesis:
In the realm of organic synthesis, Hexahydro-2H-benzo[b][1,4]oxazin-3(4H)-one is utilized as a key building block, enabling the creation of a diverse array of chemical compounds. Its presence in reactions can lead to the production of molecules with specific therapeutic or functional properties.
Used in Chemical Reactions and Processes:
Due to its distinctive structural features, Hexahydro-2H-benzo[b][1,4]oxazin-3(4H)-one is also employed in various chemical reactions and processes. It plays a crucial role in facilitating specific transformations and the synthesis of target molecules, further expanding its utility in the chemical industry.

Upstream product

• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 105-36-2 ethyl bromoacetate 
• 95628-91-4 rac-trans-N-(2'-Hydroxycyclohexyl)-2-chloroacetamide 

Downstream Products

• 134961-97-0 rac-trans-2-carboxymethoxycyclohexylammonium chloride 
• 74572-19-3 (±)-(4aR*,8aR*)-octahydro-2H-1,4-benzoxazine 
• 142034-79-5 (1R,2R)-2-Carbomethoxycyclohexylammonium chloride 
• 134962-01-9 trans-2-(2'-tosylaminocyclohexyloxy)acetic acid 
• 134962-03-1 trans-2-<2'-(N'-phenylthioureido)cyclohexyloxy>acetic acid 
• 134962-02-0 trans-2-<2'-(N'-phenylureido)cyclohexyloxy>acetic acid 
• 134962-04-2 trans-2-(2'-t-butyloxycarbonylaminocyclohexyloxy)acetic acid 
• 134962-00-8 trans-2-(2'-ethylsulfonylaminocyclohexyloxy)acetic acid 
• 134961-99-2 trans-2-(2'-methylsulfonylaminocyclohexyloxy)acetic acid 
• 134961-98-1 trans-2-(2'-acetylaminocyclohexyloxy)acetic acid 

Relevant academic research and scientific papers

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

Trans-2-acylaminocyclohexyloxyacyldipeptides in the form of mixtures of diastereoisomers thereof and in the form of pure diasteredisomers, process for the preparation thereof and pharmaceutical compositions containing the same

There are described novel trans-2-acylaminocyclohexyloxyacyldipeptides of formula I STR1 wherein R1 represents --CO--R6, --SO2 --R7 or STR2 R6 is C1 -C18 alkyl or C1 -C18 alkoxy, R7 is C1 -C18 alkyl or an optionally substituted phenyl group, Y is =O, =S or =NH; R2 =R3 and represent --H or C1 -C12 alkyl, R4 represents --OR8 or --NHR9, R8 is --H, C1 -C8 alkyl or benzyl, R9 is --H, a straight or branched chain C1 -C18 alkyl group or benzyl group; R5 represents --OR9 or --NHR9, and novel (1R,2R)- and (1S,2S)-trans-2-acylaminocyclohexyloxyacetyldipeptides of the formulas Ia and Ib STR3 wherein R1 is --CO--R6, R6 is C1 -C18 alkyl, R2 is --H, R3 is --H or C1 -C12 alkyl, R4 is --OR8 or --NHR9, R8 is --H, C1 -C8 alkyl or benzyl, R9 is --H, C1 -C18 alkyl or benzyl, R5 is --OR9 or --NHR9 Compounds of formula I, Ia and Ib and the pharmaceutically acceptable alkali salts thereof show immunomodulatory and antitumour activities and can be used in the preparation of medicaments.

Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues

The preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-isoglutamine and (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-glutamic acid is described. The title compounds were synthesized using two independent synthetic routes from racemic trans-2-azidocyclohexanol and (1R,2R)-/(1S,2S)-2-aminocyclohexanol, respectively.

A Convenient Synthesis of Trans-2-alkyl-octahydro-2H-1,4-benzoxazin-3-ones

Trans-octahydro-2H-1,4-benzoxazin-3-one and its 2-alkyl derivatives can be conveniently prepared from trans-2-azidocyclohexanol and corresponding α-haloacids.