142034-79-5Relevant articles and documents
Trans-2-acylaminocyclohexyloxyacyldipeptides in the form of mixtures of diastereoisomers thereof and in the form of pure diasteredisomers, process for the preparation thereof and pharmaceutical compositions containing the same
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, (2008/06/13)
There are described novel trans-2-acylaminocyclohexyloxyacyldipeptides of formula I STR1 wherein R1 represents --CO--R6, --SO2 --R7 or STR2 R6 is C1 -C18 alkyl or C1 -C18 alkoxy, R7 is C1 -C18 alkyl or an optionally substituted phenyl group, Y is =O, =S or =NH; R2 =R3 and represent --H or C1 -C12 alkyl, R4 represents --OR8 or --NHR9, R8 is --H, C1 -C8 alkyl or benzyl, R9 is --H, a straight or branched chain C1 -C18 alkyl group or benzyl group; R5 represents --OR9 or --NHR9, and novel (1R,2R)- and (1S,2S)-trans-2-acylaminocyclohexyloxyacetyldipeptides of the formulas Ia and Ib STR3 wherein R1 is --CO--R6, R6 is C1 -C18 alkyl, R2 is --H, R3 is --H or C1 -C12 alkyl, R4 is --OR8 or --NHR9, R8 is --H, C1 -C8 alkyl or benzyl, R9 is --H, C1 -C18 alkyl or benzyl, R5 is --OR9 or --NHR9 Compounds of formula I, Ia and Ib and the pharmaceutically acceptable alkali salts thereof show immunomodulatory and antitumour activities and can be used in the preparation of medicaments.
Synthesis and Functionalization of trans-2-(2'-Aminocyclohexyloxy)- and trans-2-(2'-Azidocyclohexyloxy)acetic Acid
Kikelj, Danijel,Krbavcic, Ales,Pecar, Slavko,Tomazic, Alenka
, p. 275 - 281 (2007/10/02)
Synthesis of the hydrochloride of trans-2-(2'-aminocyclohexyloxy)acetic acid (4) from trans-2-(2'-azidocyclohexyloxy)acetic acid (1) is described. 4 was acylated at the amino group to give compounds 5-8. 1 was converted into acid chloride (9) and amides 1
