1279696-00-2

Upstream product

• 85-44-9 phthalic anhydride 
• 56709-97-8 4-chloro-2-phenyl-phthalazin-1(2H)-one 
• 72754-31-5 4-hydrazino-2-phenyl-phthalazin-1(2H)-one 
• 100-63-0 phenylhydrazine 
• 5439-98-5 4-hydroxy-2-phenylphthalazin-1(2H)-one 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 1346229-14-8 4-(tert-butylamino)-2-phenylphthalazin-1(2H)-one 
• 1415647-86-7 4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carbonyl azide 
• 16015-51-3 methyl 4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxylate 
• 791638-32-9 2-[Methoxy(oxo)acetyl]benzoesaeure 
• 14736-50-6 o-(methoxycarbonylmethyl)benzoic acid 

Downstream Products

• 1279696-11-5 C₁₉H₁₃N₃O₃ 
• 1279696-21-7 4-(2,4-dimethoxyphenylureido)-2-phenylphthalazin-1(2H)-one 
• 1279696-22-8 4-(2,5-dimethoxyphenylureido)-2-phenylphthalazin-1(2H)-one 
• 1279696-15-9 C₂₁H₁₅ClN₄O₂ 
• 1279696-18-2 4-(2-methoxyphenyl)ureido-2-phenylphthalazin-1(2H)-one 
• 1279696-08-0 C₂₁H₁₅N₃O₂ 
• 1279696-13-7 C₂₁H₁₆N₄O₂ 
• 1279696-19-3 C₂₂H₁₈N₄O₂ 
• 1279696-10-4 C₂₂H₁₇N₃O₃ 
• 1279696-16-0 C₂₂H₁₈N₄O₃ 
• 1279696-20-6 C₂₂H₁₈N₄O₂ 
• 1279696-03-5 4-acetylamino-2-phenylphthalazin-1(2H)-one 
• 1279696-06-8 4-diacetylamino-2-phenylphthalazin-1(2H)-one 
• 1279696-23-9 C₂₂H₁₈N₄O₂ 

Relevant academic research and scientific papers

Multicomponent synthesis of 4-aminophthalazin-1(2 H)-ones by palladium-catalyzed isocyanide insertion

4-Aminophthalazin-1(2H)-ones (APOs) are underexplored heterocyclic compounds with promising and diverse biological activities. The classical synthesis of these compounds is tedious and does not allow the regioselective introduction of substituents. Here,

Facile synthesis of novel 7-aminofuro- and 7-aminothieno[2,3-d]pyridazin- 4(5H)-one and 4-aminophthalazin-1(2H)-ones

We hereby report the synthesis of a novel class of compounds, 7-aminofuro- and 7-aminothieno[2,3-d]pyridazin-4(5H)-one and 4-aminophthalazin-1(2H)-ones starting from methyl 2-(2-methoxy-2-oxoethyl)furan- and thiophene-3-carboxylate and methyl 2-(2-methoxy

The identification of the 2-phenylphthalazin-1(2 H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A 3 adenosine receptor antagonists

Following a molecular simplification approach, we have identified the 2-phenylphthalazin-1(2H)-one (PHTZ) ring system as a new decorable core skeleton for the design of novel hA3 adenosine receptor (AR) antagonists. Interest for this new series was driven by the structural similarity between the PHTZ skeleton and both the 2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one (TQX) and the 4-carboxamido-quinazoline (QZ) scaffolds extensively investigated in our previously reported studies. Our attention was focused at position 4 of the phthalazine nucleus where different amido and ureido moieties were introduced (compounds 2-20). Some of the new PHTZ compounds showed high hA3 AR affinity and selectivity, the 2,5-dimethoxyphenylphthalazin-1(2H)-one 18 being the most potent and selective hA3 AR antagonist among this series (Ki = 0.776 nM; hA1/hA3 and hA 2A/hA3 > 12000). Molecular docking studies on the PHTZ derivatives revealed for these compounds a binding mode similar to that of the previously reported TQX and QZ series, as was expected from the simplification approach.