3261-90-3

Upstream product

• 17812-07-6 Benzoylacrylic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 591-50-4 iodobenzene 
• 32856-59-0 3-(4-methoxyphenyl)dihydrofuran-2,5-dione 
• 1279698-12-2 ethyl 3-(4-methoxyphenyl)-2-nitro-5-oxo-5-phenylpentanoate 
• 3261-89-0 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile 

Downstream Products

• 93321-56-3 3-(4-methoxy-phenyl)-5-phenyl-3H-furan-2-one 
• 97861-42-2 3-(4-methoxyphenyl)-5-phenyl-2(5H)-furanone 
• 3261-92-5 2-(4'-methoxyphenyl)-α-tetralone 
• 1253042-21-5 1-isobutyl-3-(4-methoxyphenyl)-5-phenyl-1H-pyrrol-2(5H)-one 
• 1253042-17-9 3-(4-methoxyphenyl)-1-phenethyl-5-phenyl-1H-pyrrol-2(5H)-one 
• 1253042-19-1 1-(4-chlorophenyl)-3-(4-methoxyphenyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one 
• 1253042-09-9 3-(4-methoxyphenyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one 
• 1253042-18-0 1-(3,5-dimethoxyphenyl)-3-(4-methoxyphenyl)-5-phenyl-1H-pyrrol-2(5H)-one 
• 24737-95-9 4-(4-methoxyphenyl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one 

Relevant academic research and scientific papers

Synthesis of 2-substituted-4-aryl-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents with cardioprotective and ulcerogenic sparing effects

Several new 2-substituted-4-aryl-6-phenylpyridazin-3(2H)-ones were synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and possible in vitro COX-2 selectivity. To critically evaluate the possibility of deleterious effects of n

Formation of γ-oxoacids and 1 H-pyrrol-2(5 H)-ones from α,β-unsaturated ketones and ethyl nitroacetate

Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus prepared into 1H-pyrrol-2(5H)-ones by reaction with primary amines under Paal-Knorr conditions is also reported.