127983-45-3

Upstream product

• 100-42-5 styrene 
• 70546-85-9 2-phenyl-3,3a,4,5,6,7-hexahydro-2H-isoxazolo<2,3-a>pyridine 
• 142749-20-0 (R)-2-((S)-2-Hydroxy-2-phenyl-ethyl)-piperidin-1-ol 
• 495-47-6 2-(2'-hydroxy-2'-phenylethyl)piperidine 
• 105147-78-2 (S)-2-((R)-1-Oxy-2,3,4,5-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol 
• 4801-58-5 N-hydroxypiperidine 
• 34418-91-2 2,3,4,5-tetrahydropyridine N-oxide 

Downstream Products

• 127983-46-4 cis-6-methyl-8-phenyl-9-oxa-1-azabicyclo<4.3.0>nonane 
• 131697-74-0 (2S,3aR)-8-Benzyl-3a-methyl-2-phenyl-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide 
• 105147-78-2 (S)-2-((R)-1-Oxy-2,3,4,5-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol 

Relevant academic research and scientific papers

Synthesis and Cycloaddition of 6-Substituted-3,4,5,6-tetrahydropyridine 1-oxides

A study of the regiochemical behaviour of the peracid induced ring opening of several hexahydro-2H-isoxazolopyridines (4), leading mainly to ketonitrones (6), has been carried out.Mercury(II) oxide oxidation of unsymmetrical N-hydroxypiperidines (1

Mercury(II) oxide oxidation of 2-substituted-N-hydroxypiperidine: A solution to the regiochemical problem

Mercury(II) oxide oxidation of N-hydroxypiperidines having tertiary alcohol group at the β position of the C(2) side chain gave aldonitrones in a highly regioselective manner.

Nitrone Cycloaddition: Peracid Oxidation of Perhydro-1,2-oxazolooxazines

Regiochemistry of peracid induced ring opening of perhydro-1,2-oxazolooxazines (2) and (6) in aprotic solvent is dictated by orientation of lone pair of electrons on nitrogen.In contrast to the case with the corresponding hexahydro-2H-isoxazol

Peracid Induced Ring Opening of Isoxazolidines. A Mechanistic Study.

Conformational analysis and mechanistic study of peracid induced ring opening of several isoxazolidines have been carried out.The orientation of the nitrogen lone pair dictates the regiochemistry of the ring opening which involves an intramolecular kinetic deprotonation of a nitroxonium ion intermediate.

Nitrone Cycloadditions: Synthesis of (+/-)-Andrachamine

The usefulness of the cycloaddition of alkenes to 2-alkyl-2,3,4,5-tetrahydropyridine oxides for the preparation of trans-2,6-dialkylpiperidines is confirmed by a stereoselective synthesis of (+/-)-andrachamine.Peroxy acid oxidation of 9-oxa-1-azabicyclononanes does not lead regioselectively to the corresponding 2-alkyl-2,3,4,5-tetrahydropyridine oxide, as had previously been claimed.

Nitrone Cycloaddition: Peroxy Acid Oxidation of 2-Phenyl-1-oxa-9-azabicyclononane

Oxidation of 2-phenyl-1-oxa-9-azabicyclononane (5) with m-chloroperoxybenzoic acid is not regioselective, in contrast to the case with the corresponding 1-oxa-8-azabicyclooctane (2; n = 1, R1 = H, R2 = Ph), affording mainly the keto-nitrone (7).On reaction with styrene in boiling toluene the latter forms the oxabicyclononane (9).