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127986-84-9

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  • Factory Price API 99% (S)-(-)-ALPHA,ALPHA-DI(2-NAPHTHYL)-2-PYRROLIDINEMETHANOL 127986-84-9 GMP Manufacturer

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127986-84-9 Usage

Chemical Properties

white to light yellow crystal powde

Check Digit Verification of cas no

The CAS Registry Mumber 127986-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,8 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 127986-84:
(8*1)+(7*2)+(6*7)+(5*9)+(4*8)+(3*6)+(2*8)+(1*4)=179
179 % 10 = 9
So 127986-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H23NO/c27-25(24-10-5-15-26-24,22-13-11-18-6-1-3-8-20(18)16-22)23-14-12-19-7-2-4-9-21(19)17-23/h1-4,6-9,11-14,16-17,24,26-27H,5,10,15H2/p+1/t24-/m0/s1

127986-84-9 Well-known Company Product Price

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  • Aldrich

  • (699837)  (S)-(−)-α,α-Di-(2-naphthyl)-2-pyrrolidinemethanol  97%

  • 127986-84-9

  • 699837-250MG

  • 783.90CNY

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  • Aldrich

  • (699837)  (S)-(−)-α,α-Di-(2-naphthyl)-2-pyrrolidinemethanol  97%

  • 127986-84-9

  • 699837-1G

  • 2,365.74CNY

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127986-84-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name dinaphthalen-2-yl-[(2S)-pyrrolidin-2-yl]methanol

1.2 Other means of identification

Product number -
Other names (S)-dinaphthalen-2-ylpyrrolidin-2-ylmethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127986-84-9 SDS

127986-84-9Relevant articles and documents

London Dispersion Interactions Rather than Steric Hindrance Determine the Enantioselectivity of the Corey–Bakshi–Shibata Reduction

Eschmann, Christian,Song, Lijuan,Schreiner, Peter R.

supporting information, p. 4823 - 4832 (2021/02/01)

The well-known Corey–Bakshi–Shibata (CBS) reduction is a powerful method for the asymmetric synthesis of alcohols from prochiral ketones, often featuring high yields and excellent selectivities. While steric repulsion has been regarded as the key director of the observed high enantioselectivity for many years, we show that London dispersion (LD) interactions are at least as important for enantiodiscrimination. We exemplify this through a combination of detailed computational and experimental studies for a series of modified CBS catalysts equipped with dispersion energy donors (DEDs) in the catalysts and the substrates. Our results demonstrate that attractive LD interactions between the catalyst and the substrate, rather than steric repulsion, determine the selectivity. As a key outcome of our study, we were able to improve the catalyst design for some challenging CBS reductions.

Organocatalytic enantioselective α-hydroxymethylation of aldehydes: Mechanistic aspects and optimization

Boeckman, Robert K.,Biegasiewicz, Kyle F.,Tusch, Douglas J.,Miller, John R.

, p. 4030 - 4045 (2015/05/05)

Further studies of the direct enantioselective α-hydroxymethylation of aldehydes employing the α,α-diarylprolinol trimethylsilyl ether class of organocatalysts are described. This process has proven efficient for access to β-hydroxycarboxylic acids and δ-hydroxy-α,β-unsaturated esters from aldehydes in generally good yields, excellent enantioselectivity, and compatibility with a broad range of functional groups in the aldehyde. The goal of these studies was to identify the critical reaction variables that influence the yield and enantioselectivity of the α-hydroxymethylation process such as catalyst structure, pH of the medium, purity of the reactants and reagents particularly with respect to the presence of acidic impurities, and the nature of the buffer, along with the standard variables including solvent, time, temperature and mixing efficiency. The previously identified intermediate lactol has been further characterized and its reactivity examined. These studies have led to identification of the most critical variables translating directly into improved substrate scope, reproducibility, enantioselectivity, and yields.

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

Gautier, Franois-Moana,Jones, Simon,Martin, Stephen J.

supporting information; experimental part, p. 229 - 231 (2009/03/11)

Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.

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