127998-29-2Relevant academic research and scientific papers
A Cp2TiCl2-Me3Al (1:4) reagent system: An efficient reagent for generation of allylic titanocene derivatives from vinyl halides, vinyl ethers and carboxylic esters
Hanzawa, Yuji,Kowase, Noboru,Momose, Shu-Ichi,Taguchi, Takeo
, p. 11387 - 11398 (2007/10/03)
The reagent prepared in advance by stirring a mixture of a Cp'2TiCl2- Me3Al (a 1:4 ratio) reagent system in toluene for 3 days is found to be effective in generating allylic titanocene on treatment with vinyl halides, vinyl ethers and carboxylic esters in THF. The process for the generation of an allylic titanocene species from these starting materials was suggested to proceed through a formation of titanacyclobutane and the subsequent elimination of the halogen or alkoxyl group. The generated allylic titanocene intermediate was proved to be an allylic Ti(IV) species and showed the typical reactivity to carbonyl compounds.
Generation of allylic titanocene derivatives from vinyl halides and a Cp2TiCl2-Me3Al reagent system
Hanzawa, Yuji,Kowase, Noboru,Taguchi, Takeo
, p. 583 - 586 (2007/10/03)
The reagent prepared in advance by stirring a mixture of a Cp2TiCl2-Me3Al reagent system in the ratio of 1 : 4 in toluene for 3 days is found to be effective in generating allylic titanocene on treatment with vinyl halides in THF.
Selective Mono- and Polymethylene Homologations of Copper Reagents Using (Iodomethyl)zinc Iodide
Sidduri, AchyuthaRao,Rozema, Michael J.,Knochel, Paul
, p. 2694 - 2713 (2007/10/02)
A wide range of unsaturated aryl-, alkenyl-, alkynylcopper compounds can be selectively homologated by a methylene unit using (iodomethyl)zinc iodide or bis(iodomethyl)zinc.These reactions allow the generation of mixed allylic zinc-copper compounds which can be efficiently trapped with carbonyl compounds.An application to a general preparation of functionalized α-methylene-γ-butyrolactones is described.The homologation of alkynylcoppers with (iodomethyl)zinc iodide allows a one-pot preparation of propargylic copper reagents which in the presence of a carbonyl compound provide various homopropargylic alcohols in excellent yields.In the absence of an electrophile, a clean quadruple methylene homologation of alkynylcoppers occurs to furnish dienic copper reagents.The homologation of other types of copper reagents is also possible, and carbanions at the α-position to amines as well as homoenolates of aldehydes or ketones can also be prepared by this method.
