1280127-44-7

Upstream product

• 81153-44-8 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 1307801-19-9 (4-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-yl)methanol 
• 1307801-17-7 ethyl 4-azido-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 

Downstream Products

• 1307801-25-7 2-(2-chlorophenyl)-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-40-6 2-(4-bromophenyl)-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine-3-carbonitrile 
• 1307801-41-7 ethyl 2,9-dimethyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine-3-carboxylate 
• 1307801-27-9 2-(4-fluorophenyl)-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-29-1 2-(4-chlorophenyl)-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-30-4 2-(4-bromophenyl)-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-42-8 2,9-dimethyl-N,7-diphenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine-3-carboxamide 
• 1307801-34-8 9-methyl-7-phenyl-2-(2,4,6-trimethoxyphenyl)-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-23-5 9-methyl-2,7-diphenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-35-9 9-methyl-7-phenyl-2-p-tolyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-21-3 2,9-dimethyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-38-2 2-ethyl-9-methyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-36-0 2,3,9-trimethyl-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1307801-37-1 2,9-dimethyl-3,7-diphenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 

Relevant academic research and scientific papers

Novel synthetic protocol toward pyrazolo[3,4-h]-[1,6]naphthyridines via Friedlander condensation of new 4-aminopyrazolo[3,4-b]pyridine-5-carbaldehyde with reactive α-methylene ketones

Novel pyrazolo[3,4-h][1,6]naphthyridine derivatives 6, 8, 9, 11, 13, and 15 have been synthesized by Friedlander condensation of new 4-amino-3-methyl-1- phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (o-aminoaldehyde) 4 with active methylene ketones, such as symmetric acetone 5a, monoalkylketones 5b-k, unsymmetrical dialkyl ketones 7a-b, p-bromophenylacetonitrile 10, β-ketoester 12a, β-ketoamide 12b, or diethyl malonate 14, respectively.