1280127-44-7Relevant articles and documents
Novel synthetic protocol toward pyrazolo[3,4-h]-[1,6]naphthyridines via Friedlander condensation of new 4-aminopyrazolo[3,4-b]pyridine-5-carbaldehyde with reactive α-methylene ketones
Jachak, Madhukar N.,Bagul, Sandeep M.,Kazi, Muddassar A.,Toche, Raghunath B.
, p. 295 - 300 (2011/06/10)
Novel pyrazolo[3,4-h][1,6]naphthyridine derivatives 6, 8, 9, 11, 13, and 15 have been synthesized by Friedlander condensation of new 4-amino-3-methyl-1- phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (o-aminoaldehyde) 4 with active methylene ketones, such as symmetric acetone 5a, monoalkylketones 5b-k, unsymmetrical dialkyl ketones 7a-b, p-bromophenylacetonitrile 10, β-ketoester 12a, β-ketoamide 12b, or diethyl malonate 14, respectively.