1307801-35-9

Upstream product

• 1280127-44-7 4-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde 
• 122-00-9 para-methylacetophenone 
• 81153-44-8 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 1307801-19-9 (4-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-yl)methanol 
• 1307801-17-7 ethyl 4-azido-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 

Relevant academic research and scientific papers

Novel synthetic protocol toward pyrazolo[3,4-h]-[1,6]naphthyridines via Friedlander condensation of new 4-aminopyrazolo[3,4-b]pyridine-5-carbaldehyde with reactive α-methylene ketones

Novel pyrazolo[3,4-h][1,6]naphthyridine derivatives 6, 8, 9, 11, 13, and 15 have been synthesized by Friedlander condensation of new 4-amino-3-methyl-1- phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (o-aminoaldehyde) 4 with active methylene ketones, such as symmetric acetone 5a, monoalkylketones 5b-k, unsymmetrical dialkyl ketones 7a-b, p-bromophenylacetonitrile 10, β-ketoester 12a, β-ketoamide 12b, or diethyl malonate 14, respectively.