203807-48-1Relevant academic research and scientific papers
Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling
Zhao, Xiao-Jing,Li, Zi-Hao,Ding, Tong-Mei,Tian, Jin-Miao,Tu, Yong-Qiang,Wang, Ai-Fang,Xie, Yu-Yang
, p. 7061 - 7065 (2021)
A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F–H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π–π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.
INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
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Page/Page column 83-84, (2012/11/06)
The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore
Boger, Dale L.,Chen, Jyun-Hung,Saionz, Kurt W.,Jin, Qing
, p. 85 - 102 (2007/10/03)
The preparation and examination of 2-22 constituting a systematic study of the chromophore of sandramycin (1) are detailed. Fluorescence quenching studies were used to establish binding constants for 1-24 within calf thymus DNA, within a single high affin
