128019-77-2

Upstream product

• 75-64-9 tert-butylamine 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 501-53-1 benzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 197911-00-5 Succinic acid mono-((3R,5S)-1-benzyloxycarbonyl-5-tert-butylcarbamoyl-pyrrolidin-3-yl) ester 
• 175798-92-2 (2S,4R)-1-benzyloxycarbonyl-2-tert-butylaminocarbonyl-4-(p-toluenesulfonyloxy)pyrrolidine 
• 197911-06-1 (2S,4S)-4-amino-1-benzyloxycarbonyl-2-tert-butylaminocarbonylpyrrolidine 
• 176047-29-3 (2S,4S)-4-azido-1-benzyloxycarbonyl-2-tert-butylaminocarbonylpyrrolidine 
• 207444-84-6 [(1S,2S)-1-Benzyl-3-((2S,4R)-2-tert-butylcarbamoyl-4-hydroxy-pyrrolidin-1-yl)-2-hydroxy-3-oxo-propyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric aldol reaction using immobilized proline on mesoporous support

The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L-proline on MCM-41 catalyzed aldol reactions in both hydr

Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120

Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.