1280217-75-5

Upstream product

• 359629-91-7 ethyl 5-bromo-2-methylbenzoate 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 1262035-46-0 1-(5-bromo-2-methylphenyl)-1-methylethanol 
• 103-73-1 Phenetole 

Downstream Products

• 1333113-38-4 C₂₄H₃₂O₆ 
• 1318793-79-1 1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-methylphenyl}-β-D-glucopyranose 
• 1333071-88-7 2,3,4,6-tetra-O-acetyl-1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-methylphenyl}-β-D-glucopyranose 

Relevant academic research and scientific papers

Gem-dimethyl-bearing C-glucosides as sodium-glucose co-transporter 2 (SGLT2) inhibitors

Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 (SGLT2) inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test (OGTT), and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin. Copyright