1280218-22-5

Basic information

• Product Name: 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
• Synonyms: 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS NO: 1280218-22-5
• Molecular Weight: 321.307
• Mol File: 1280218-22-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one(1280218-22-5)
• EPA Substance Registry System: 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one(1280218-22-5)

Safety Data

• Hazardous Substances Data: 1280218-22-5(Hazardous Substances Data)

Upstream product

• 770-31-0 4-amino-2-(methylthio)pyrimidine-5-carbaldehyde 
• 717-30-6 2-(2,4-difluorophenoxy)acetic acid ethyl ester 
• 105161-35-1 4-amino-2-sulfanylpyrimidine-5-carbaldehyde 
• 367-27-1 2,4-difluorophenol 

Downstream Products

• 1280218-42-9 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1313610-16-0 6-(2,4-difluorophenoxy)-2-methanesulfonyl-8-(2-methanesulfonylethyl)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-08-7 6-(2,4-difluorophenoxy)-8-(2-methanesulfonylethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-36-1 6-(2,4-difluorophenoxy)-2-methanesulfonyl-8-(3-methanesulfonylpropyl)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-09-8 6-(2,4-difluorophenoxy)-8-(3-methanesulfonylpropyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-43-0 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-11-2 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-45-2 6-(2,4-difluorophenoxy)-8-((S)-2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-46-3 6-(2,4-difluorophenoxy)-8-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-12-3 6-(2,4-difluorophenoxy)-8-((S)-2,3-dihydroxypropyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-48-5 [6-(2,4-difluorophenoxy)-2-methanesulfonyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]acetonitrile 
• 1280218-13-4 [6-(2,4-difluorophenoxy)-7-oxo-2-(tetrahydropyran-4-ylamino)-7H-pyrido[2,3-d]pyrimidin-8-yl]acetonitrile 
• 1280218-26-9 6-(2,4-difluorophenoxy)-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1280218-07-6 6-(2,4-difluorophenoxy)-8H-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

Inhibitor containing fused ring derivative as well as preparation method and application thereof

The invention relates to an inhibitor containing fused ring derivative as well as a preparation method and application thereof. Particularly, the invention relates to a compound as shown in a generalformula (I), a preparation method thereof, a pharmaceuti

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl) propylamino]-8-methyl-8 H -pyrido[2,3- d ]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2 H -pyran-4-ylamino)pyrido[2,3- d ]pyrimidin-7(8 H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase

The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.