1280219-85-3

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 183312-49-4 1-(2-(phenylethynyl)phenyl)prop-2-yn-1-ol 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 536-74-3 phenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 1394324-99-2 C₁₀H₅(Sn(C₄H₉)3)(C₆H₄Cl)C(O)C₆H₅ 

Relevant academic research and scientific papers

Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

A highly efficient CoI2/o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

Platinum-catalyzed tandem cycloisomerization reaction of benzoendiynyl esters: Regioselective long-range 1,5-Acyl migration

A PtII-catalyzed intramolecular chemo- and regioselective pentannulation/long-range 1,5-acyl migration reaction is described. This cascade cycloisomerization protocol produces a wide variety of benzofulvene diketones in good to excellent yields with exclusively the Z configuration of the exocyclic double bond of the final product. The 18O isotope experiment together with 13C NMR, HRMS, and HMBC analyses confirmed an interesting long-range acyl rearrangement process in this transformation.

Gold-catalyzed cascade friedel-crafts/furan-yne cyclization/heteroenyne metathesis for the highly efficient construction of phenanthrene derivatives

A rapid access to highly substituted phenanthrenyl ketones through gold-catalyzed cyclization of 1,6-diyn-4-en-3-ols with furans has been developed. Gold catalysts are effective to catalyze three cascade processes involving Friedel-Crafts/furan-yne cyclization/heteroenyne metathesis through C-O bond and alkyne activation. This method offers several advantages such as high selectivities and easily accessible starting materials.