1280786-80-2

Basic information

• Product Name: 5-Bromo-3-chloro-2-fluorobenzaldehyde
• Synonyms: 5-Bromo-3-chloro-2-fluorobenzaldehyde
• CAS NO: 1280786-80-2
• Molecular Formula: C₇H₃BrClFO
• Molecular Weight: 237.4535232
• Mol File: 1280786-80-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Bromo-3-chloro-2-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-chloro-2-fluorobenzaldehyde(1280786-80-2)
• EPA Substance Registry System: 5-Bromo-3-chloro-2-fluorobenzaldehyde(1280786-80-2)

Safety Data

• Hazardous Substances Data: 1280786-80-2(Hazardous Substances Data)

Usage

Uses

5-Bromo-3-chloro-2-fluorobenzaldehyde is used in the preparation of peptide macrocycles for the treatment of diseases and infection caused by Acinetobacter baumannii.

Upstream product

• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1514304-24-5 (5-bromo-3-chloro-2-fluorophenyl)methanol 
• 1386459-84-2 (5-bromo-3-chloro-2-fluorophenyl)methanamine 

Relevant articles and documents

HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX).

PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII

The present invention provides compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.

CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The invention generally relates to cyclic compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof and pharmaceutical comopositions comprising the multicyclic compounds. The invention also relates to a method for treating a disease or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, an inflammatory diseases or an immune system disease (e.g., a T-Cell mediated autoimmune disesase) in a subject in need thereof. The method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, or a composition comprising a compound of the invention, or a pharmaceutically acceptable salt thereof.