1281100-68-2

Upstream product

• 51627-98-6 ethyl 2-(4 fluorophenyl)ethanimidoate hydrochloride 
• 134-20-3 2-carbomethoxyaniline 
• 459-22-3 4-fluorophenylacetonitrile 
• 28144-70-9 anthranilic acid amide 
• 201230-82-2 carbon monoxide 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 615-43-0 2-iodophenylamine 

Relevant academic research and scientific papers

Synthesis and evaluation of α-glucosidase and pancreatic lipase inhibition by quinazolinone-coumarin hybrids

A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and α-glucosidase inhibition properties. Among the synthesized compounds, N'-{2-[2-(3,4-dichlorobenzyl)-4-oxoquinazolin-3(4H)-yl]acetyl}-2-oxo-2H-chromene-3-carbohydrazide and N'-{2-[2-(4-bromobenzyl)-4-oxoquinazolin-3(4H)-yl]acetyl}-2-oxo-2H-chromene-3-carbohydrazide showed the best inhibitory effect against α-glucosidase with IC50 values of 6.11 ± 0.40 and 7.34 ± 0.37 μM, respectively. These compounds also showed strong anti-lipase activity (IC50 3.52 ± 0.49 and 2.85 ± 0.27 μM, respectively).

Microwave-assisted synthesis of some 2-substituted quinazolin-4(3H)-one derivatives from iminoester hydrochlorides

Herein, a method that involves a reaction of iminoester hydrochloride with methyl anthranilate via microwave assisted synthesis is reported. This efficient procedure provides pure products within few minutes. This method can be used as a general technique for synthesizing quinazoline derivatives.

One-pot synthesis of 4(3H)-quinazolinones from azides, alkynes, anilines, and carbon monoxide

A one-pot synthesis of 4(3H)-quinazolinones from terminal alkynes, sulphonyl azide, o-iodoanilines, and carbon monoxide has been developed. This cascade process includes the copper-catalyzed three-component reaction of alkyne, azide and amine, the palladium-catalyzed carbonylation, and the Lewis acid catalyzed hydrolysis of sulfonamide.