136010-55-4Relevant academic research and scientific papers
Inhibitors of retroviral proteases
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, (2008/06/13)
The present invention relates to compounds of the formula I STR1 wherein A, Y, R2, R3, R4, R5, R6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.
Renin inhibitors containing a pyridyl amino diol derived C-terminus
Heitsch,Henning,Kleemann,Linz,Nickel,Ruppert,Urbach,Wagner
, p. 2788 - 2800 (2007/10/02)
Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy- 6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibition
PEPTIDYL AMINODIOL RENIN INHIBITORS
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, (2008/06/13)
A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.
Renin-inhibiting functionalized peptidyl aminodiols and - triols
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, (2008/06/13)
A renin inhibiting compound of the formula: or a pharmaceutically acceptable salt, ester or prodrug thereof.
