47091-20-3Relevant articles and documents
Selective C-N bond oxidation: demethylation of N-methyl group in N-arylmethyl-N-methyl-α-amino esters utilizing N-iodosuccinimide (NIS)
Katoh, Takahiro,Watanabe, Tsunefumi,Nishitani, Mitsuyoshi,Ozeki, Minoru,Kajimoto, Tetsuya,Node, Manabu
, p. 598 - 600 (2008/09/16)
Demethylation of N-methyl group in N-methyl-N-arylmethyl-α-amino esters was accomplished by the oxidation of the amino group using the N-iodosuccinimide (NIS)/acetonitrile system followed by treatment with O-methylhydroxylamine hydrochloride. This combina
Total synthesis of the cyclic depsipeptide leualacin
McLaren
, p. 6082 - 6084 (2007/10/03)
The fungal metabolite leualacin (1), a potent calcium channel antagonist, was synthesized in 15 steps from commercially available amino acids in 25% overall yield using standard solution methods. The synthesis is general and thus would accommodate the incorporation of amino acid replacements as well as the inclusion of peptide mimics and isosteres.