128200-13-5

Basic information

• Product Name: 1-Azabicyclo(2,2,2)octan-3-ol-3-aminomethyl
• Synonyms: 1-Azabicyclo(2,2,2)octan-3-ol-3-aminomethyl;3-Aminomethyl-1-aza-bicyclo[2.2.2]octan-3-ol;3-(AMINOMETHYL)QUINUCLIDIN-3-OL
• CAS NO: 128200-13-5
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 155.2175
• Mol File: 128200-13-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Azabicyclo(2,2,2)octan-3-ol-3-aminomethyl(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azabicyclo(2,2,2)octan-3-ol-3-aminomethyl(128200-13-5)
• EPA Substance Registry System: 1-Azabicyclo(2,2,2)octan-3-ol-3-aminomethyl(128200-13-5)

Safety Data

• Hazardous Substances Data: 128200-13-5(Hazardous Substances Data)

Usage

Structure

Bicyclic with a nitrogen atom

Usage

Synthesis of pharmaceuticals (atropine, scopolamine)

Medical Applications

Treatment of various medical conditions

Chirality

Contains a chiral center, exists in two enantiomeric forms

Biological Activity

Different enantiomers have distinct biological activities

Research

Studied for potential use in Parkinson's disease and other neurological disorders

Versatility

Building block in organic chemistry

Applications

Wide range of potential applications in medicinal and pharmaceutical chemistry

Structural Properties

Unique structural and chemical properties contribute to its versatility

Upstream product

• 6238-30-8 3-hydroxy-1-azabicyclo[2.2.2]octane-3-carbonitrile 
• 138272-89-6 2-ethylspiro(1,3-oxazoline-5,3')quinuclidine 
• 802294-64-0 propionic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 128653-87-2 (3-(aminomethyl)-3-hydroxy-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate 

Downstream Products

• 617-36-7 Ethyl oxamate 
• 144333-72-2 4-Amino-5-chloro-N-(3-hydroxy-1-azabicyclo[2.2.2]oct-3-ylmethyl)-2-methoxybenzamide, monohydrochloride 
• 138925-60-7 [2'-(1H-Indazole-3-yl)-]spiro(1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazole) hydrochloride 

Relevant articles and documents

3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols

3-[N-Aroyl(or thioaryol)aminoalkyl]-3-quinuclidinols corresponding to the formula: STR1 wherein X is O or S, and Ar is phenyl, substituted phenyl, indole, indazole or pyrimidine; optical isomers and the pharmaceutically acceptable acid addition salts and solvates thereof. These compounds have gastric emptying, antiemetic, anxiolytic and selective serotonin modulating or inhibiting activity.

SPIRO NITROGEN-BRIDGED HETEROCYCLIC COMPOUNDS

The invention relates to novel compounds (I) for treating diseases of the central and peripheral nervous system: STR1 including enantiomers, racemates and acid addition and quaternary salts thereof, wherein one of X and Y is O and the other of X and Y is N; Q is (CH 2) n or C(CH. sub.3) 2 where n is 1, 2 or 3 and the bridge--Q--is attached at one end to position 1 and at the other end to position 4 or 5, and R° is hydrogen, methyl or hydroxyl; in the moiety STR2 the line connecting Z and Y signifies a double bond when X--Z is O--C--R and Y is N, and a single bond when X--Z is N=C--R and Y is O; Z is C--R wherein R is selected from hydrogen, NH 2, NH-R" (R"=C 1-6-alkyl) , N(R") 2, R", C 2-6-alkenyl, C 2-6-alkynyl, C 3-7-cycloalkyl, R" substituted by hydroxy or by 1-6 halogen atoms, R"O-C 1-6-alkyl, carboxy-C 1-6-alkyl, R"OCO-C 1-6-alkyl, amino-C 1-6-alkyl, R"NH-C 1-6-alkyl, (R") 2 N-C 1-6-alkyl, 2-oxo-pyrrolidin-1-ylmethyl, aryl, diarylmethylol, and R" substituted by one or two aryl groups, wherein aryl denotes phenyl optionally substituted by 1-3 halogens, R", R"O and(or) CF 3. Also claimed are compounds wherein the line connecting Z and Y signifies the absence of a bond, X is O, Z is H and Y is NH 2, NO 2 or N 3. "