617-36-7Relevant academic research and scientific papers
Synthetic route to isotopically labelled-oxamate
Siwek, Agata,Trotsko, Nazar,Wujec, Monika,Kaminski, Rafal,Paneth, Piotr
, p. 344 - 344 (2011)
Since none of the available methods was suitable for the synthesis of isotopically labelled oxamate, a new procedure has been developed in our laboratory, based on the known procedures, but with substantial modifications. The method is convenient and gives reproducibly 17% yield based on KCN used. The strategy is considered suitable for labelling oxamate with 15N and 13C or 14C when starting with labelled KCN and can be easily modified for the synthesis of 18O-carbonyl-labelled oxamate. Copyright 2011 John Wiley & Sons, Ltd. Synthesis route to sodium oxamate labelled with various isotopes has been proposed. Copyright
Oxidative Coupling of Diazo and NH4I: A Route to Primary Oxamates and α-Ketoamides
Fang, Shangwen,Li, Jingjing,Wan, Xiaobing,Wang, Hanghang,Zhao, Yanwei,Zheng, Yonggao
supporting information, p. 3050 - 3058 (2020/03/23)
A simple and efficient method has been developed for the preparation of primary oxamates and α-ketoamides through the oxidative coupling of diazo compounds and NH4I. Under the optimized reaction conditions, a range of diazoesters and α-diazoketones was explored, and the corresponding products were obtained in moderate to good yields. This protocol is metal-free, is performed under mild conditions, has a wide substrate scope, and offers operational simplicity.
Method for preparing oxamide ester
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Paragraph 0022-0023, (2019/09/05)
The invention discloses a method for preparing oxamide ester. A diazonium ester compound and ammonium iodide are adopted as reaction substrates, t-butylhydroperoxide (TBHP) is adopted as an environment-friendly oxidant under the condition of having no transition metal and alkali, and the oxamide ester is obtained through an oxidative coupling reaction in an organic solvent. Compared with the priorart, the method has the following advantages that the range of the reaction substrates is wide, reaction conditions are mild, the operation is simple, and the environment is protected. According to the method, TBHP is used as the oxidant, tert-butanol and water are produced after the reaction, the use of oxidants such as iodobenzene acetate and sodium hypochlorite is avoided, no harm is caused tothe environment, and the requirements of contemporary environment-friendly chemistry are met. In addition, the method can be used for post-modification of natural active molecules, such as cholesterol and epiandrosterone, a final target product with a high yield can be obtained, and a foundation is laid for practical application.
Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles
Westwood, Matthew T.,Lamb, Claire J. C.,Sutherland, Daniel R.,Lee, Ai-Lan
supporting information, p. 7119 - 7123 (2019/09/03)
Direct C-H acylations and carbamoylations of heterocycles can now be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex molecules, including pharmaceuticals, N,N-ligands, and light-sensitive molecules.
Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide
Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.
supporting information, p. 1060 - 1063 (2016/10/17)
A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.
Extremely simple but long overlooked: Generation of α-Azido alcohols by hydroazidation of aldehydes
Banert, Klaus,Berndt, Christian,Firdous, Samia,Hagedorn, Manfred,Joo, Young-Hyuk,Rueffer, Tobias,Lang, Heinrich
supporting information; experimental part, p. 10206 - 10209 (2011/02/27)
Discovered by accident: Just because an example of a simple substructure cannot be found in literature does not mean that corresponding compounds are not readily accessible. α-Azido alcohols like 1-azidoethanol have now been prepared and isolated. Copyright
Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione
Kunde, Lalita B.,Kalyani, Vishwanath S.,Gupte, Sunil P.
experimental part, p. 402 - 407 (2010/08/06)
Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol
DECOMPOSITION PRODUCTS OF HALONITROACETIC ACID DERIVATIVES
Yurtanov, A. I.
, p. 120 - 122 (2007/10/02)
The halonitro group O2NCHX of chloro- and bromonitroacetic acid derivatives underwent reduction to H2NCO upon boiling.The same derivatives decomposed to oxalic acid upon long storage.Likely chemical transformation pathways are discussed. Keywords: chloro- and bromonitroacetic acids, reduction, oxalic acid, amides.
Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid
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, (2008/06/13)
This invention relates to substances represented by Formula (I), wherein X stands for either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which R is an alkyl of 1 to 4 carbon atoms, or a (CH2)nNR'2 group wherein n is 2 or 3 while R' is a methyl or ethyl group; eventually X may represent morpholinyl. Also considered are salts of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid with appropriate inorganic or organic bases represented by Formula (II) wherein B is either an alkaline metal cation, alkaline earth cation, cyclohexylamine cation, or lysine cation. Said substances are characterized by anti-inflammatory properties comparable to (and greater than) the initial acid while simultaneously said modifications of their physico-chemical properties broaden the possibilities of their therapeutic application.
SPIRO NITROGEN-BRIDGED HETEROCYCLIC COMPOUNDS
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, (2008/06/13)
The invention relates to novel compounds (I) for treating diseases of the central and peripheral nervous system: STR1 including enantiomers, racemates and acid addition and quaternary salts thereof, wherein one of X and Y is O and the other of X and Y is N; Q is (CH 2) n or C(CH. sub.3) 2 where n is 1, 2 or 3 and the bridge--Q--is attached at one end to position 1 and at the other end to position 4 or 5, and R° is hydrogen, methyl or hydroxyl; in the moiety STR2 the line connecting Z and Y signifies a double bond when X--Z is O--C--R and Y is N, and a single bond when X--Z is N=C--R and Y is O; Z is C--R wherein R is selected from hydrogen, NH 2, NH-R" (R"=C 1-6-alkyl) , N(R") 2, R", C 2-6-alkenyl, C 2-6-alkynyl, C 3-7-cycloalkyl, R" substituted by hydroxy or by 1-6 halogen atoms, R"O-C 1-6-alkyl, carboxy-C 1-6-alkyl, R"OCO-C 1-6-alkyl, amino-C 1-6-alkyl, R"NH-C 1-6-alkyl, (R") 2 N-C 1-6-alkyl, 2-oxo-pyrrolidin-1-ylmethyl, aryl, diarylmethylol, and R" substituted by one or two aryl groups, wherein aryl denotes phenyl optionally substituted by 1-3 halogens, R", R"O and(or) CF 3. Also claimed are compounds wherein the line connecting Z and Y signifies the absence of a bond, X is O, Z is H and Y is NH 2, NO 2 or N 3. "
