128200-58-8

Upstream product

• 98-88-4 benzoyl chloride 
• 165621-52-3 2-(trimethylsilyl)ethyl 2,6-di-O-benzoyl-β-D-galactopyranoside 
• 117252-95-6 2-(trimethylsilyl)ethyl β-D-galactopyranoside 
• 128200-57-7 Ethyl 1-thio-2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-β-D-galactopyranoside 

Downstream Products

• 195323-25-2 2-(trimethylsilyl)ethyl 2,3,6-tri-O-benzoyl-4-O-levulinoyl-β-D-galactopyranoside 
• 211677-98-4 2-(trimethylsilyl)ethyl (2-azido-3,4,6-tri-O-benzyl-2-deoxy-α-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-galactopyranoside 
• 128200-55-5 2-(Trimethylsilyl)ethyl-2,3,6-tri-O-benzoyl-4-O-(3-O-allyl-2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-β-D-galactopyranoside 
• 195323-32-1 2-(tetradecyl)hexadecyl 2,3,6-tri-O-benzoyl-4-O-levulinoyl-β-D-galactopyranoside 
• 195323-33-2 2-(tetradecyl)hexadecyl 2,3,6-tri-O-benzoyl-β-D-galactopyranoside 
• 195323-29-6 2,3,6-tri-O-benzoyl-4-O-levulinoyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate 
• 260976-38-3 2-(trimethylsilyl)ethyl (4-azido-2,3,6-tri-O-benzyl-4-deoxy-α-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-galactopyranoside 
• 260976-43-0 2-(trimethylsilyl)ethyl (6-azido-2,3,4-tri-O-benzyl-6-deoxy-α-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis of some amino and carboxy analogs of galabiose; evaluation as inhibitors of the pilus protein PapG(J)96 from Escherichia coli

The 2'-amino-2'-deoxy, 6-amino-6-deoxy, and 6-carboxy analogs of the reference inhibitor 2(trimethylsilyl)ethyl (α-D-galactopyranosyl)-(1→4)- β-d-galactopyranoside were synthesized and evaluated as inhibitors of the binding of the Escherichia coli-derived pilus protein PapG(J96), using an ELISA assay. The inhibitory efficiencies (K(rel); relative to the reference inhibitor) were: 157, 13, and 8, respectively. The results support the previously proposed combining site model, where the protein carries a negatively charged amino acid residue near HO-2' and HO-6 of the galabioside.

Synthetic studies on selectin ligands/inhibitors: A systematic sysnthersis of sulfatide and its higher congeners carrying 2-(tetradecyl)hexadecyl group as a ceramide substitute

A systematic synthesis of sulfatide (I) and novel sulfatide analogs (II-VI) carrying 2-(tetradecyl)hexadecyl group as a ceramide substitute is described. The 3-O-, 4-O-and 3,4-di-O-levulinoyl derivatives of galactopyranosyl trichloroacetimidates (1, 12, and 13) were coupled with (2S,3R,4E)-3-O-acetyl-2-octadecanamido-4-octadecene-1,3-diol or 2-(tetradecyl)hexadecan-1-ol. The resulting glycolipids (2, 4, 14, and 15) were each transformed, by selective removal of the levulinoyl group(s), and successive sulfation and de-O-acylation, into the 3-sulfates (I, II), 4-sulfate (III), and 3,4-disulfate (IV). The 6-sulfate (V) was prepared from 2-(tetradecyl)hexadecyl β-D-galactopyranoside (21) via the 6-0-t-butyldimethylsilyl derivative, while the 3'-sulfate of 2-(tetradecyl)hexadecyl β-D-lactoside (VI) was synthesized from 2-(trimethylsilyl)ethyl 3'-O-benzyl-β-D-lactoside (26). The structures of the sulfated glycolipids (I-VI) were characterized by ion-spray MS, MS/MS, and 1H NMR spectrometry.

METHOD FOR TREATING GALABIOSE-BINDING BACTERIA INFECTIONS

A method for treating infections caused by galabiose-binding bacteria using galabiose derivatives modified at the 3 and anomeric positions. The galabiose-derivatives and compositions of some are also disclosed