128238-43-7

Basic information

• Product Name: 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL
• Synonyms: 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL;TFA-ABU(4)-OL;TFA-NH-(CH2)4-OH;N-TRIFLUOROACETYL-DELTA-AMINO-N-BUTYL ALCOHOL;N-TRIFLUOROACETYL-4-AMINO-1-BUTANOL;N-(4-HYDROXYBUTYL)TRIFLUOROACETAMIDE;4-(trifluoroacetamido)-1-butanol
• CAS NO: 128238-43-7
• Molecular Formula: C₆H₁₀F₃NO₂
• Molecular Weight: 185.14
• Mol File: 128238-43-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 257.5°C at 760 mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.262 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00216mmHg at 25°C
• Refractive Index: n20/D 1.413
• PKA: 11.30±0.46(Predicted)
• BRN: 6644043
• CAS DataBase Reference: 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL(128238-43-7)
• EPA Substance Registry System: 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL(128238-43-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 128238-43-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10F3NO2/c7-6(8,9)5(12)10-3-1-2-4-11/h11H,1-4H2,(H,10,12)

Upstream product

• 13325-10-5 4-Aminobutanol 
• 383-63-1 ethyl trifluoroacetate, 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1333028-07-1 methyl 4-[(1-azido-4-trifluoroacetamidobutoxy)methyl]benzoate 
• 32548-24-6 1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one 
• 663600-58-6 4-[(4,4'-dimethoxytrityl)oxy]butanamine 
• 1094764-71-2 O-(dibenzyloxyphosphoryl)-4-trifluoroacetamido-1-butanol 
• 876746-11-1 C₃₃H₄₁F₃NO₇P 

Relevant articles and documents

Rapid Synthesis of Bicyclic N-Heterocyclic Cores from N-Terminal α,β-Unsaturated Diazoketones

A method for the synthesis of bicyclic N-heterocyclic cores from N-terminal α,β-unsaturated diazoketones has been developed. The transformation involves three sequential steps that include N-deprotection, an intramolecular aza-Michael, and a photochemical Wolff rearrangement as a one-pot protocol. By using this strategy, a series of substituted bicyclic N-heterocycles, particularly, indolizidines and pyrrolizidines, were synthesize in good yields.

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

Micro-RMA inhibitor

The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two or more complementary sequences are linked via one or more linker residues.