1282461-33-9

Basic information

• Product Name: 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide
• Synonyms: 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide
• CAS NO: 1282461-33-9
• Molecular Weight: 577.633
• Mol File: 1282461-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide(1282461-33-9)
• EPA Substance Registry System: 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide(1282461-33-9)

Safety Data

• Hazardous Substances Data: 1282461-33-9(Hazardous Substances Data)

Upstream product

• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 84832-01-9 methyl 2,6-difluoro-3-nitrobenzoate 
• 84832-02-0 methyl 3-amino-2,6-difluorobenzoate 
• 896114-82-2 6-nitro-2-phenyl-3H-imidazo[4,5-b]pyridine 
• 896114-83-3 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine 
• 3537-14-2 5-nitro-pyridine-2,3-diamine 
• 3073-30-1 3,5-dinitropyridin-2-amine 
• 1186193-95-2 methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate 

Downstream Products

• 1186223-07-3 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide 

Relevant articles and documents

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.