896114-82-2

Usage

Heterocyclic compound

1H-Imidazo[4,5-b]pyridine, 6-nitro-2-phenylis a compound that contains a ring of atoms with at least one nitrogen atom.

Nitro group

A functional group consisting of an oxygen and a nitrogen atom (-NO2) attached to the 6th position of the imidazo[4,5-b]pyridine ring system.

Phenyl group

A functional group consisting of a six-membered carbon ring with five hydrogen atoms and one substituent attached to the 2nd position of the imidazo[4,5-b]pyridine ring system.

Building block in synthesis

This chemical is commonly used as a starting material or building block in the synthesis of more complex pharmaceutical compounds and organic materials.

Electronic or optical properties

This chemical may also have uses in the synthesis of organic materials with specific electronic or optical properties.

Upstream product

• 100-52-7 benzaldehyde 
• 3537-14-2 5-nitro-pyridine-2,3-diamine 
• 2578-45-2 2-chloro-3,5-dinitropyridine 
• 3073-30-1 3,5-dinitropyridin-2-amine 
• 65-85-0 benzoic acid 

Downstream Products

• 1282461-33-9 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide 
• 1186223-07-3 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide 
• 896114-83-3 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine 

Relevant academic research and scientific papers

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.

IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Benzamide Derivatives, Their Manufacture and Use as Pharmaceutical Agents

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.