1282523-32-3Relevant academic research and scientific papers
Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
Dou, Xiaowei,Yao, Weijun,Zhou, Bo,Lu, Yixin
, p. 9224 - 9226 (2013/09/24)
Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.
Organocatalytic michael-alkylation cascade: The enantioselective nitrocyclopropanation of oxindoles
Pesciaioli, Fabio,Righi, Paolo,Mazzanti, Andrea,Bartoli, Giuseppe,Bencivenni, Giorgio
supporting information; experimental part, p. 2842 - 2845 (2011/04/24)
The spiro saga goes on! The title reaction sequence provides the first enantioselective synthesis of spiro nitrocyclopropyl oxindoles. The method provides easy access to these new, biologically inspired compounds from readily available starting materials
