1398566-57-8Relevant academic research and scientific papers
Method for preparation of chiral chlorooxindole derivatives
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Paragraph 0046; 0047; 0051; 0052; 0053; 0054; 0055, (2016/10/24)
Derivatives of chiral chloro jade poet pebble is disclosure is manufacturing method. The present invention refers to, chiral organic catalyst in the presence, (E)-2-( (E)-2-arylnitroethene [...]) isoindoline chloro 3-derivatives and-2-on (3-chloroindoline-2-one) derivatives characterized in that reaction.
Michael addition of N-unprotected 2-oxindoles to nitrostyrene catalyzed by bifunctional tertiary amines: Crucial role of dispersion interactions
Reiter, Christoph,Lopez-Molina, Sonia,Schmid, Bernhard,Neiss, Christian,Goerling, Andreas,Tsogoeva, Svetlana B.
, p. 1324 - 1332 (2014/05/20)
Bifunctional thiourea- or sulfonamide-derived tertiary amines catalyze the enantioselective nitro-Michael addition of N-unprotected 3-substituted 2-oxindoles to nitrostyrene in up to 99 % yields, 94:6 er, and 87:13 dr. Overcoming the necessity to introduc
Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
Dou, Xiaowei,Yao, Weijun,Zhou, Bo,Lu, Yixin
supporting information, p. 9224 - 9226 (2013/09/24)
Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.
Organocatalytic asymmetric synthesis of 3-chlorooxindoles bearing adjacent quaternary-tertiary centers
Noole, Artur,Jaerving, Ivar,Werner, Franz,Lopp, Margus,Kanger, Tonis,Malkov, Andrei
supporting information, p. 4922 - 4925,4 (2012/12/12)
A new methodology was developed for the synthesis of enantiomerically enriched 3,3-disubstituted 3-chlorooxindoles 3 via a Michael addition of 3-chloroxindoles to nitroolefins 2, catalyzed by chiral squaramide 10. Products with adjacent quaternary-tertiary centers were isolated in excellent yields (up to 99%), high diastereoselectivities (up to 11:1), and enantiomeric purities (up to 92%). This is the first example where 3-chloroxoindoles 1 have been used as nucleophiles in a highly stereoselective organocatalytic reaction.
Organocatalytic asymmetric synthesis of 3-chlorooxindoles bearing adjacent quaternary-tertiary centers
Noole, Artur,J?rving, Ivar,Werner, Franz,Lopp, Margus,Malkov, Andrei,Kanger, T?nis
supporting information, p. 4922 - 4925 (2013/01/15)
A new methodology was developed for the synthesis of enantiomerically enriched 3,3-disubstituted 3-chlorooxindoles 3 via a Michael addition of 3-chloroxindoles to nitroolefins 2, catalyzed by chiral squaramide 10. Products with adjacent quaternary-tertiar
