1456887-56-1

Upstream product

• 68235-96-1 rac-3-chloroindolin-2-one 
• 102-96-5 (2-nitroethenyl)benzene 
• 1398566-57-8 (R)-3-chloro--3-((S)-2-nitro-1-phenylethyl)indolin-2-one 

Downstream Products

• 1282523-32-3 (1S,2S,3R)-tert-butyl 3-nitro-2'-oxo-2-phenylspiro[cyclopropane-1,3'-indoline]-1'-carboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.