1282531-72-9

Upstream product

• 1185465-25-1 tert-butyl [2-(3-isocyanatophenyl)ethyl]carbamate 
• 1185465-65-9 tert-butyl [2-(3-{[(biphenyl-2-ylamino)carbonyl]amino}phenyl)ethyl]-carbamate 
• 621-50-1 (3-nitrophenyl)acetonitrile 
• 83304-13-6 2-(3-nitrophenyl)ethylamine 
• 619-23-8 3-Nitrobenzyl chloride 
• 180079-94-1 N-(3-aminophenylmethyl)methylcarbamic acid t-butyl ester 
• 180079-93-0 N-(3-nitrophenylmethyl)methylcarbamic acid t-butyl ester 

Downstream Products

• 1185465-69-3 N-{3-[2-({(2R,S)-2-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl}amino)ethyl]phenyl}-N'-biphenyl-2-ylurea 
• 1185463-90-4 N-biphenyl-2-yl-N'-[3-(2-{[(2RS)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}ethyl)phenyl]urea 

Relevant academic research and scientific papers

Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists

The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β1/β2-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and duration of action, and we have discovered a strong correlation in this series of molecules. A quantitative structure-activity relationship (QSAR) analysis will be presented that quantifies this relationship.