128345-57-3

Basic information

• Product Name: (S)-3-Aminopyrrolidine
• Synonyms: PYRROLIDIN-(S)-3-YLAMINE;(S)-(-)-3-AMINOPYRROLIDINE;(S)-3-AMINOPYRROLIDINE;S-AP;(3S)-(-)-3-AMINOPYRROLIDINE;(3S)-(-)-AMINOPYRROLIDINE;(3S)-PYRROLIDINAMINE;3-(S)-PYRROLIDINEAMINE
• CAS NO: 128345-57-3
• Molecular Formula: C₄H₁₀N₂
• Molecular Weight: 86.14
• Product Categories: pharmacetical;chiral;3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 128345-57-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 164-165 °C(lit.)
• Flash Point: 155 °F
• Appearance: /
• Density: 0.967 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 9.94±0.20(Predicted)
• Sensitive: Air Sensitive & Hygroscopic
• BRN: 4290648
• CAS DataBase Reference: (S)-3-Aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Aminopyrrolidine(128345-57-3)
• EPA Substance Registry System: (S)-3-Aminopyrrolidine(128345-57-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 128345-57-3(Hazardous Substances Data)

Usage

Uses

(S)-3-Aminopyrrolidine is used in preparation of Heterocyclic spiro-compounds as AM2 receptor inhibitors.

Upstream product

• 114715-38-7 (3S)-1-benzyl-3-pyrrolidinamine 
• 56440-28-9 (S)-3-amino-2-pyrrolidinone hydrochloride 
• 79286-79-6 pyrrolidin-3-amine 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 

Downstream Products

• 132195-48-3 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 146560-56-7 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 146560-54-5 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-2-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 146560-55-6 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(2-fluoro-4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 179739-88-9 1-(3-amino-2,4-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 
• 956468-08-9 N-((3S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-pyrrolidinyl)-3,4-bis(methyloxy)benzenesulfonamide 
• 749844-54-0 (S) 8-(3-aminopyrrolidin-1-yl)-7-(2-bromobenzyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione 
• 485820-45-9 (S) 8-(3-aminopyrrolidin-1-yl)-7-(2-bromobenzyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione hydrochloride 
• 99724-19-3 3-(tert-butoxycarbonylamino)pyrrolidine 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 

Relevant articles and documents

Synthesis of 6-oxopyrimidin-1(6H)-yl benzamide derivatives and evaluation of their antibacterial and cytotoxic activity

A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations.

PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLIC COMPOUND

A nitrogenous heterocyclic compound such as 3-aminopyrrolidine derivative is produced by hydrogenolysis of an N-substituted nitrogenous heterocyclic compound with normal pressure hydrogen in a water-based solvent in presence of a catalyst. In the case an optically active 1-substituted-3-aminopyrrrolidine derivative is used as a raw material, an optically active 3-aminopyrrolidine derivative can be obtained as a product practically without racemination.

Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative

A method for making an optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) includes cyclizing an optically active asparagine ester derivative represented by the formula (1) or (2) or an acid salt thereof. The optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) may be reduced to form an optically active 3-aminopyrrolidine derivative represented by the formula (9). When, in the formula (9), R1 is an unsubstituted or substituted benzyl group, the compound may be hydrogenated to obtain the corresponding 1-unsubstituted compound in which R1 is hydrogen.